Protection of Retinal Ganglion Cells and Retinal Vasculature by Lycium Barbarum Polysaccharides in a Mouse Model of Acute Ocular Hypertension 英文参考文献.docVIP
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Protection of Retinal Ganglion Cells and Retinal Vasculature by Lycium Barbarum Polysaccharides in a Mouse Model of Acute Ocular Hypertension 英文参考文献
ProtectionofRetinalGanglionCellsandRetinal
VasculaturebyLyciumBarbarumPolysaccharidesina
MouseModelofAcuteOcularHypertension
Xue-SongMi1,2,QianFeng2,AmyCheukYinLo4,RaymondChuen-ChungChang2,BinLin2,4 ,Sookja
KimChung2,Kwok-FaiSo2,3,5*
1DepartmentofOphthalmology,theFirstAffiliatedHospitalofJinanUniversity,Guangzhou,Guangdong,China,2DepartmentofAnatomyandtheStateKeyLaboratory
ofBrainandCognitiveScience,LiKaShingFacultyofMedicine,TheUniversityofHongKong,HongKong,China,3ResearchCentreofHeart,Brain,HormoneandHealthy
Aging,LiKaShingFacultyofMedicine,TheUniversityofHongKong,HongKong,China,4EyeInstitute,LiKaShingFacultyofMedicine,TheUniversityofHongKong,
HongKong,China,5TheJointLaboratoryforBrainFunctionandHealth(BFAH),JinanUniversityandTheUniversityofHongKong,HongKong,China
Abstract
Acuteocularhypertension(AOH)isaconditionfoundinacuteglaucoma.Thepurposeofthisstudyistoinvestigatethe
protectiveeffectofLyciumbarbarumpolysaccharides(LBP)anditsprotectivemechanismsintheAOHinsult.LBPhasbeen
shown to exhibit neuroprotective effect in the chronic ocular hypertension (COH) experiments. AOH mouse model was
induced in unilateral eye for one hour by introducing 90mmHg ocular pressure. The animal was fed with LBP solution
(1mg/kg) or vehicle daily from 7 days before the AOH insult till sacrifice at either day 4 or day 7 post insult. The
neuroprotective effects of LBP on retinal ganglion cells (RGCs) and blood-retinal-barrier (BRB) were evaluated. In control
AOHretina,lossofRGCs,thinningofIRLthickness,increasedIgGleakage,brokentightjunctions,anddecreaseddensityof
retinalbloodvesselswereobserved.However,inLBP-treatedAOHretina,therewaslesslossofRGCswiththinningofIRL
thickness,IgGleakage,morecontinuedstructureoftightjunctionsassociatedwithhigherlevelofoccludinproteinandthe
recovery of the blood vessel density when compared with vehicle-treated AOH retina. Moreover, we found that LBP
provides neuroprotection by down-regulating RAGE, ET-1, Ab and AGE in the retina, as well as their related s
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