Protection against West Nile Virus Infection in Mice after Inoculation with Type I Interferon-Inducing RNA Transcripts 英文参考文献.docVIP

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Protection against West Nile Virus Infection in Mice after Inoculation with Type I Interferon-Inducing RNA Transcripts 英文参考文献.doc

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Protection against West Nile Virus Infection in Mice after Inoculation with Type I Interferon-Inducing RNA Transcripts 英文参考文献

ProtectionagainstWestNileVirusInfectioninMiceafter InoculationwithTypeIInterferon-InducingRNA Transcripts MiguelRodr?′guez-Pulido1.,MiguelA.Mart?′n-Acebes2.¤,EstelaEscribano-Romero2 ,Ana- Bele′nBla′zquez2,FranciscoSobrino1,Bele′nBorrego3,MargaritaSa′iz1,Juan-CarlosSaiz2* 1Centro de Biolog?′a Molecular Severo Ochoa, Consejo Superior de Investigaciones Cient?′ficas-Universidad Auto′noma de Madrid (CSIC-UAM), Madrid, Spain, 2Departamento de Biotecnolog?′a, Instituto Nacional de Investigacio′n y Tecnolog?′a Agraria y Alimentaria (INIA), Madrid, Spain, 3Centro de Investigacio′n en Sanidad Animal,InstitutoNacionaldeInvestigacio′nyTecnolog?′aAgrariayAlimentaria(CISA-INIA),Madrid,Spain Abstract WestNilevirus(WNV)isaneurovirulentsinglestrandedRNAmosquito-borneflavivirus,whosemainnaturalhostsarebirds, butitalsoinfectshumansandhorses.Nowadays,nohumanvaccineiscommerciallyavailableandclinicaltreatmentisonly supportive. Recently, it has been shown that RNA transcripts, mimicking structural domains in the non-coding regions (NCRs) of the foot-and mouth disease virus (FMDV) induce a potent IFN response and antiviral activity in transfected cultured cells, and also reduced mice susceptibility to FMDV. By using different transcripts combinations, administration schedules,andinfectingroutesanddoses,wehavedemonstratedthattheseFMDVRNAtranscriptsprotectsucklingand adult mice against lethal challenge with WNV. The protective activity induced by the transcripts was systemic and dependentontheinfectionrouteanddose.TheseresultsconfirmtheantiviralpotentialofthesesyntheticRNAsforfighting virusesofdifferentfamiliesrelevantforhumanandanimalhealth. Citation:Rodr?′guez-PulidoM,Mart?′n-AcebesMA,Escribano-RomeroE,Bla′zquez A-B,SobrinoF,etal.(2012)ProtectionagainstWestNileVirusInfectioninMice afterInoculationwithTypeIInterferon-InducingRNATranscripts.PLoSONE7(11):e49494.doi:10.1371/journal.pone.0049494 Editor:TianWang,UniversityofTexasMedicalBranch,UnitedStatesofAmerica ReceivedJuly18,2012;Acce