Prophylactic and Therapeutic Vaccination against Hepatitis C Virus (HCV) Developments and Future Perspectives 英文参考文献.docVIP

下载本文档

4
0
约7.74万字
约 22页
2017-05-13 发布于上海
举报
版权申诉

Prophylactic and Therapeutic Vaccination against Hepatitis C Virus (HCV) Developments and Future Perspectives 英文参考文献.doc

1、本文档共22页，可阅读全部内容。
2、原创力文档（book118）网站文档一经付费（服务费），不意味着购买了该文档的版权，仅供个人/单位学习、研究之用，不得用于商业用途，未经授权，严禁复制、发行、汇编、翻译或者网络传播等，侵权必究。
3、本站所有内容均由合作方或网友上传，本站不对文档的完整性、权威性及其观点立场正确性做任何保证或承诺！文档内容仅供研究参考，付费前请自行鉴别。如您付费，意味着您自己接受本站规则且自行承担风险，本站不退款、不进行额外附加服务；查看《如何避免下载的几个坑》。如果您已付费下载过本站文档，您可以点击这里二次下载。
4、如文档侵犯商业秘密、侵犯著作权、侵犯人身权等，请点击“版权申诉”（推荐），也可以打举报电话：400-050-0827(电话支持时间：9:00-18:30)。
5、该文档为VIP文档，如果想要下载，成为VIP会员后，下载免费。
6、成为VIP后，下载本文档将扣除1次下载权益。下载后，不支持退款、换文档。如有疑问请联系我们。
7、成为VIP后，您将拥有八大权益，权益包括：VIP文档下载权益、阅读免打扰、文档格式转换、高级专利检索、专属身份标志、高级客服、多端互通、版权登记。
8、VIP文档为合作方或网友上传，每下载1次，网站将根据用户上传文档的质量评分、类型等，对文档贡献者给予高额补贴、流量扶持。如果你也想贡献VIP文档。上传文档

Prophylactic and Therapeutic Vaccination against Hepatitis C Virus (HCV) Developments and Future Perspectives 英文参考文献

Viruses 2009, 1, 144-165; doi:10.3390/v1020144 OPEN ACCESS viruses ISSN 1999-4915 /journal/viruses Review Prophylactic and Therapeutic Vaccination against Hepatitis C Virus (HCV): Developments and Future Perspectives Marian E. Major Division of Viral Products, Center for Biologics, Food and Drug Administration, Bldg29A/Rm1D10, 8800 Rockville Pike, Bethesda, MD 20892, USA; E-mail: marian.major@; Tel.: +1-301-827-1881; Fax: +1-301-496-1810 Received: 3 June 2009; in revised form: 25 July 2009 / Accepted: 11 August 2009 / Published: 12 August 2009 Abstract: Studies in patients and chimpanzees that spontaneously clear Hepatitis C Virus (HCV) have demonstrated that natural immunity to the virus is induced during primary infections and that this immunity can be cross protective. These discoveries led to optimism regarding prophylactic HCV vaccines and a number of studies in the chimpanzee model have been performed, all of which resulted in modified infections after challenge but did not always prevent persistence of the virus. Therapeutic vaccine strategies have also been pursued in an effort to reduce the costs and side effects associated with anti-viral drug treatment. This review summarizes the studies performed thus far in both patients and chimpanzees for prophylactic and therapeutic vaccination, assesses the progress made and future perspectives. Keywords: vaccine; immune responses; immunotherapy; T cells; neutralizing antibody 1. Introduction Hepatitis C virus (HCV) is an enveloped virus with a single stranded, plus sense RNA genome. The RNA (~9.6 kb in length) consists of a ~341-base 5 non-translated region (NTR), a single open reading frame encoding all virus-specific proteins (~3011 amino acids), and a 3 NTR. Translation of the genome RNA is cap-independent and mediated by the 5 NTR which functions as an internal ribosome entry site. The resulting polyprotein is cleaved, both co- and post-transla