Protective Effects of Fluoxetine on Decompression Sickness in Mice 英文参考文献.docVIP

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Protective Effects of Fluoxetine on Decompression Sickness in Mice 英文参考文献.doc

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Protective Effects of Fluoxetine on Decompression Sickness in Mice 英文参考文献

ProtectiveEffectsofFluoxetineonDecompression SicknessinMice Jean-EricBlatteau1*,SandrineBarre1,AureliePascual1,OlivierCastagna1,JacquesH.Abraini2 ,Jean- JacquesRisso1,NicolasVallee1 1Equipe Re′sidante de Recherche Subaquatique Ope′rationnelle. Institut de Recherche Biome′dicale des Arme′es - Toulon, De′partement Environnement Ope′rationnel, Unite′ EnvironnementsExtre?mes, Toulon,France,2Universite′ deCaenBasseNormandie,Caen,FranceCentreHospitalierAffilie′ Universite′ LavalHo?tel-DieudeLe′vis, Le′vis,Quebec,Canada Abstract Massivebubbleformationafterdivingcanleadtodecompressionsickness(DCS)thatcanresultincentralnervoussystem disorders or even death. Bubbles alter the vascular endothelium and activate blood cells and inflammatory pathways, leadingtoasystemicpathophysiologicalprocessthatpromotesischemicdamage.Fluoxetine,awell-knownantidepressant, isrecognizedashavinganti-inflammatorypropertiesatthesystemiclevel,aswellasinthesettingofcerebralischemia.We reportabeneficialclinicaleffectassociatedwithfluoxetineinexperimentalDCS.91miceweresubjectedtoasimulateddive at 90 msw for 45min before rapid decompression. The experimental group received 50mg/kg of fluoxetine 18 hours beforehyperbaricexposure(n=46)whilecontrolswerenottreated(n=45).Clinicalassessmenttookplaceoveraperiodof 30minaftersurfacing.Attheend,bloodsampleswerecollectedforbloodcellscountsandcytokineIL-6detection.There were significantly fewer manifestations of DCS in the fluoxetine group than in the controls (43.5% versus 75.5%, respectively;p=0.004).Survivorsshowedabetterandsignificantneurologicalrecoverywithfluoxetine.Plateletsandred cells were significantly decreased after decompression in controls but not in the treated mice. Fluoxetine reduced circulatingIL-6,arelevantmarkerofsystemicinflammationinDCS.Weconcludedthatfluoxetinedecreasedtheincidenceof DCSandimprovedmotorrecovery,bylimitinginflammationprocesses. Citation:BlatteauJ-E,BarreS,PascualA,CastagnaO,AbrainiJH,etal.(2012)ProtectiveEffectsofFluoxe