Protective Effect of Tetrahydroxystilbene Glucoside on 6-OHDA-Induced Apoptosis in PC12 Cells through the ROS-NO Pathway 英文参考文献.docVIP

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Protective Effect of Tetrahydroxystilbene Glucoside on 6-OHDA-Induced Apoptosis in PC12 Cells through the ROS-NO Pathway 英文参考文献.doc

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Protective Effect of Tetrahydroxystilbene Glucoside on 6-OHDA-Induced Apoptosis in PC12 Cells through the ROS-NO Pathway 英文参考文献

ProtectiveEffectofTetrahydroxystilbeneGlucosideon 6-OHDA-InducedApoptosisinPC12Cellsthroughthe ROS-NOPathway LizhenTao1,XiaofengLi1,LinglingZhang1,JiyuTian1,XiaobingLi1,XinSun1,XuefenLi1,LinJiang1, XiaojunZhang2*,JianzongChen1* 1Research Center of Traditional Chinese Medicine, Xijing Hospital, Fourth Military Medical University, Xi’an, People’s Republic of China, 2Department of Physics and Mathematics,SchoolofBiomedicalEngineering,FourthMilitaryMedicalUniversity,Xi’an,People’sRepublicofChina Abstract Oxidativestressplaysanimportantroleinthepathogenesisofneurodegenerativediseases,suchasParkinson’sdisease.The molecule, 2,3,5,49-tetrahydr- oxystilbene-2-O-b-D-glucoside (TSG), is a potent antioxidant derived from the Chinese herb, Polygonum multiflorum Thunb. In this study, we investigated the protective effect of TSG against 6-hydroxydopamine- inducedapoptosisinratadrenalpheochromocytomaPC12cellsandthepossiblemechanisms.Ourdatademonstratedthat TSG significantly reversed the 6-hydroxydopamine-induced decrease in cell viability, prevented 6-hydroxydopamine- induced changes in condensed nucleiand decreased the percentage of apoptotic cells in a dose-dependent manner. In addition, TSG slowed the accumulation of intracellular reactive oxygen species and nitric oxide, counteracted the overexpressionofinduciblenitricoxidesynthesesaswellasneuronalnitricoxidesyntheses,andalsoreducedthelevelof protein-bound 3-nitrotyrosine. These results demonstrate that the protective effects of TSG on rat adrenal pheochromocytomaPC12cellsaremediated,atleastinpart,bytheROS-NOpathway.OurresultsindicatethatTSGmay beeffectiveinprovidingprotectionagainstneurodegenerativediseasesassociatedwithoxidativestress. Citation:TaoL,LiX,ZhangL,TianJ,LiX,etal.(2011)ProtectiveEffectofTetrahydroxystilbeneGlucosideon6-OHDA-InducedApoptosisinPC12Cellsthrough theROS-NOPathway.PLoSONE6(10):e26055.doi:10.1371/journal.pone.0026055 Editor:MarkR.Cookson,NationalInstitutesofHealth,UnitedStatesofAmerica ReceivedJuly