Proteomics paves the way for Q fever diagnostics 英文参考文献.docVIP

Kowalczewska et al. Genome Medicine 2011,3:50 /content/3/7/50 RE VIE W Proteomics paves the way for Q fever diagnostics Malgorzata Kowalczewska *, Zuzana Sekeyová and Didier Raoult 1 2 1 Presentation of the disease is extremely variable. A non- immunized person develops a primary infection in 60% of cases (Table 1). is can lead to the acute disease (in 40% of cases), which mostly presents as a ?u-like syn- drome or as severe pneumonia; 2% of patients with acute disease are hospitalized [1]. In patients with pre-existing valvulopathy, infection can progress to the chronic form (in 2-5% of patients), which is characterized by blood- culture-negative endocarditis [1,4]. e fever and charac- teristic vegetations (a mixture of bacteria and blood clots on heart valves) are frequently absent, making diagnosis di?cult [1]. Importantly, Q fever is associated with high morbidity and mortality in pregnant women [1,4], although only few such cases have been reported to date [2,4]. e incidence of Q fever was recently re-evaluated by analyzing Q fever data collected at the French National Reference Center (FNRC) between 1985 and 2009 [5]. During this 25-year period, the FNRC identi?ed 32 out- breaks in Europe, indicating that the number of Q fever cases was increasing [5]. Abstract Q fever is a worldwide zoonosis caused by Coxiella burnetii. The disease most frequently manifests clinically as a self-limited febrile illness, as pneumonia (acute Q fever) or as a chronic illness that presents mainly as infective endocarditis. The extreme infectivity of the bacterium results in large outbreaks, and the recent outbreak in the Netherlands underlines its impact on public health. Recent studies on the bacterium have included genome sequencing, the investigation of host-bacterium interactions, the development of cellular and animal m