Pruritus a useful sign for predicting the haemodynamic changes that occur following administration of vancomycin 英文参考文献.docVIP

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Pruritus a useful sign for predicting the haemodynamic changes that occur following administration of vancomycin 英文参考文献.doc

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Pruritus a useful sign for predicting the haemodynamic changes that occur following administration of vancomycin 英文参考文献

Critical Care June 2002 Vol 6 No 3 Bertolissi et al. Research Pruritus: a useful sign for predicting the haemodynamic changes that occur following administration of vancomycin Massimo Bertolissi1, Flavio Bassi2, Roberta Cecotti3, Carlo Capelli4 and Francesco Giordano5 1Senior Staff Consultant, Second Department of Anesthesia and Intensive Care Medicine, Azienda Ospedaliera, S. Maria della Misericordia, Udine, Italy 2Consultant, Second Department of Anesthesia and Intensive Care Medicine, Azienda Ospedaliera, S. Maria della Misericordia, Udine, Italy 3Resident, Second Department of Anesthesia and Intensive Care Medicine, Azienda Ospedaliera, S. Maria della Misericordia, Udine, Italy 4Professor, Institute of Human Physiology, Udine University, Italy 5Director, Second Department of Anesthesia and Intensive Care Medicine, Azienda Ospedaliera, S. Maria della Misericordia, Udine, Italy Correspondence: Massimo Bertolissi, bertolissi@ Received: 25 March 2002 Accepted: 3 April 2002 Published: 25 April 2002 Critical Care 2002, 6:234-239 ? 2002 Bertolissi et al., licensee BioMed Central Ltd (Print ISSN 1364-8535; Online ISSN 1466-609X) Abstract Introduction The aim of this study was to investigate the haemodynamic changes that follow the appearance of pruritus during vancomycin administration. Methods We studied 50 patients scheduled for coronary artery bypass surgery, and we compared data from patients who exhibited pruritus with those from patients who did not. After the monitoring devices had been positioned, vancomycin (15 mg/kg) was continuously infused at a constant rate over 30 min, before induction of anaesthesia. Haemodynamic profiles were recorded before vancomycin infusion (time point 1); at 15 (time point 2) and 30 min (time point 3) after the beginning of vancomycin infusion; and 15 min after vancomycin infusion had been stopped (time point 4). At each time arterial and mixed venous blood samples were drawn to calculate the shunt f