Radical-scavenging Activity of Natural Methoxyphenols vs. Synthetic Ones using the Induction Period Method 英文参考文献.docVIP

Molecules 2007, 12, 130-138 molecules ISSN 1420-3049 Full Paper Radical-scavenging Activity of Natural Methoxyphenols vs. Synthetic Ones using the Induction Period Method Yoshinori Kadoma 1, Toshiko Atsumi 2, Norihisa Okada 2, Mariko Ishihara 2, Ichiro Yokoe 3 and Seiichiro Fujisawa 2,* 1 Institute of Biomaterials and Bioengineering, Tokyo Medical and Dental University, Kanda- surugadai, Chiyoda-ku, Tokyo 101-0062, Japan; E-mail: y-kadoma.fm@tmd.ac.jp 2 Meikai Unversity School of Dentistry, Sakado, Saitama 3500283, Japan; E-mails: tosi@dent.meikai.ac.jp, okada@dent.meikai.ac.jp, mariko@dent.meikai.ac.jp 3 Faculty of Pharmaceutical Sciences, Josai University, Saitama 3500295, Japan; E-mail: yokoe@josai.ac.jp * Author to whom correspondence should be addressed; E-mail: fujisawa33@ Received: 22 January 2007; in revised form: 31 January 2007 / Accepted: 1 February 2007 / Published: 3 February 2007 Abstract: The radical-scavenging activities of the synthetic antioxidants 2-allyl-4-X- phenol (X=NO2, Cl, Br, OCH3, COCH3, CH3, t-(CH3)3, C6H5) and 2,4-dimethoxyphenol, and the natural antioxidants eugenol and isoeugenol, were investigated using differential scanning calorimetry (DSC) by measuring their anti-1,1-diphenyl-2-picrylhydrazyl (DPPH) radical activity and the induction period for polymerization of methyl methacrylate (MMA) initiated by thermal decomposition of 2,2-azobisisobutyronitrile (AIBN) and benzoyl peroxide (BPO). 2-Allyl-4-methoxyphenol and 2,4-dimethoxy- phenol scavenged not only oxygen-centered radicals (PhCOO.) derived from BPO, but also carbon-centered radicals (R.) derived from the AIBN and DPPH radical much more efficiently, in comparison with eugenol and isoeugenol. 2-Allyl-4-methoxyphenol may be useful for its lower prooxidative activity Keywords: Radical-scavenging activity; natural and synthetic methoxyphenols; DPPH; BPO, AIBN; induction method.  Molecules 2007, 12 13