Rapid molecular detection of methicillin-resistant Staphylococcus aureus a cost-effective tool for infection control in critical care 英文参考文献.docVIP

Available online /content/10/2/128 Commentary Rapid molecular detection of methicillin-resistant Staphylococcus aureus: a cost-effective tool for infection control in critical care? Marc J Struelens and Olivier Denis Department of Microbiology, Université Libre de Bruxelles – Hopital Erasme, Brussels, Belgium Corresponding author: Marc J Struelens, marc.struelens@ulb.ac.be Published: 14 March 2006 Critical Care 2006, 10:128 (doi:10.1186/cc4855) This article is online at /content/10/2/128 ? 2006 BioMed Central Ltd See related research by Harbarth et al. in issue 10.1 [/content/10/1/R25] Abstract The implementation of rapid PCR screening reduced the time to detection of MRSA carriers from 4 days to 1 day. After implementing extensive on-admission PCR screening and pre-emptive contact isolation, a substantial decrease of MRSA infections was observed in the medical ICU but not in the surgical ICU. Using the PCR method, the number of Control strategies for methicillin-resistant Staphylococcus aureus (MRSA) in critical care remain debated. Timely detection of MRSA carriers is crucial to an effective isolation policy. In this issue, Harbarth and colleagues report rapid MRSA screening among intensive care unit-admitted patients using a PCR assay. Pre- emptive isolation for all admissions until screened negative for MRSA was associated with a reduction of intensive care unit- acquired MRSA infections in one of two study units. The data provide preliminary evidence to the effectiveness of a MRSA control strategy combining rapid screening by a molecular method and preventive isolation. Further controlled studies are needed to evaluate the cost-effectiveness of this intervention. unnecessary isolation days was markedly reduced as compared with the same isolation policy supported by conventional screening methods. Rationale for impro