Reassortant H9N2 Influenza Viruses Containing H5N1-Like PB1 Genes Isolated from Black-Billed Magpies in Southern China 英文参考文献.docVIP

下载本文档

4
0
约 10页
2017-05-13 发布于上海
举报
版权申诉

Reassortant H9N2 Influenza Viruses Containing H5N1-Like PB1 Genes Isolated from Black-Billed Magpies in Southern China 英文参考文献.doc

1、原创力文档（book118）网站文档一经付费（服务费），不意味着购买了该文档的版权，仅供个人/单位学习、研究之用，不得用于商业用途，未经授权，严禁复制、发行、汇编、翻译或者网络传播等，侵权必究。。
2、本站所有内容均由合作方或网友上传，本站不对文档的完整性、权威性及其观点立场正确性做任何保证或承诺！文档内容仅供研究参考，付费前请自行鉴别。如您付费，意味着您自己接受本站规则且自行承担风险，本站不退款、不进行额外附加服务；查看《如何避免下载的几个坑》。如果您已付费下载过本站文档，您可以点击这里二次下载。
3、如文档侵犯商业秘密、侵犯著作权、侵犯人身权等，请点击“版权申诉”（推荐），也可以打举报电话：400-050-0827(电话支持时间：9:00-18:30)。
4、该文档为VIP文档，如果想要下载，成为VIP会员后，下载免费。
5、成为VIP后，下载本文档将扣除1次下载权益。下载后，不支持退款、换文档。如有疑问请联系我们。
6、成为VIP后，您将拥有八大权益，权益包括：VIP文档下载权益、阅读免打扰、文档格式转换、高级专利检索、专属身份标志、高级客服、多端互通、版权登记。
7、VIP文档为合作方或网友上传，每下载1次，网站将根据用户上传文档的质量评分、类型等，对文档贡献者给予高额补贴、流量扶持。如果你也想贡献VIP文档。上传文档

Reassortant H9N2 Influenza Viruses Containing H5N1-Like PB1 Genes Isolated from Black-Billed Magpies in Southern China 英文参考文献

ReassortantH9N2InfluenzaVirusesContainingH5N1- LikePB1GenesIsolatedfromBlack-BilledMagpiesin SouthernChina GuoyingDong1,2.,CongXu3.,ChengminWang1,BinWu1,JingLuo1,HongZhang1,DaleLouisNolte4, ThomasJudeDeliberto4,MingxingDuan5,GuangjuJi2*,HongxuanHe1* 1KeyLaboratoryofAnimalEcologyandConservationBiology,NationalResearchCenterForWildlifeBornDiseases,InstituteofZoology,ChineseAcademyofSciences, Beijing,China,2NationalLaboratoryofBiomacromolecules,InstituteofBiophysicsofChineseAcademyofSciences,Beijing,China,3CollegeofFoodScience,Southwest University,Chongqing,China,4NationalWildlifeDiseaseProgram,USDA/APHIS/WildlifeServices,UnitedStatesDepartmentofAgriculture,FortCollins,Colorado,United StatesofAmerica,5StateKeyLaboratoryofBiomembraneandMembraneBiotechnology,SchoolofLifeSciences,TsinghuaUniversity,Beijing,China Abstract H9N2 influenza A viruses have become endemic in different types of terrestrial poultry and wild birds in Asia, and are occasionallytransmittedtohumansandpigs.Toevaluatetheroleofblack-billedmagpies(Picapica)intheevolutionof influenzaAvirus,weconductedtwoepidemicsurveysonavianinfluenzavirusesinwildblack-billedmagpiesinGuangxi, China in 2005 and characterized three isolated black-billed magpie H9N2 viruses (BbM viruses). Phylogenetic analysis indicatedthatthreeBbMviruseswerealmostidenticalwith99.7to100%nucleotidehomologyintheirwholegenomes,and werereassortantscontainingBJ94-like (Ck/BJ/1/94) HA,NA,M,andNSgenes,SH/F/98-like (Ck/SH/F/98) PB2,PA,andNP genes,andH5N1-like(Ck/YN/1252/03,clade1)PB1genes.GeneticanalysisshowedthatBbMvirusesweremostlikelythe resultofmultiplereassortmentsbetweenco-circulatingH9N2-likeandH5N1-likeviruses,andweregeneticallydifferentfrom other H9N2 viruses because of the existence of H5N1-like PB1 genes. Genotypical analysis revealed that BbM viruses evolvedfromdiversesourcesandbelongedtoanovelgenotype(B46)discoveredinourrecentstudy.Molecularanalysis suggested that BbM viruses were likely low pathogenic reassortants. However, results