Reassortant between Human-Like H3N2 and Avian H5 Subtype Influenza A Viruses in Pigs A Potential Public Health Risk 英文参考文献.docVIP

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Reassortant between Human-Like H3N2 and Avian H5 Subtype Influenza A Viruses in Pigs A Potential Public Health Risk 英文参考文献.doc

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Reassortant between Human-Like H3N2 and Avian H5 Subtype Influenza A Viruses in Pigs A Potential Public Health Risk 英文参考文献

ReassortantbetweenHuman-LikeH3N2andAvianH5 SubtypeInfluenzaAVirusesinPigs:APotentialPublic HealthRisk YanlongCong1.,GuangmeiWang1.,ZhenhongGuan2.,ShuangChang1,QuanpengZhang1 ,Guilian Yang3,WeiliWang4,QingfengMeng4,WeimingRen3,ChunfengWang3*,ZhuangDing1* 1CollegeofAnimalScienceandVeterinaryMedicine,JilinUniversity,Changchun,Jilin,China,2InstituteofZoonoses,JilinUniversity,Changchun,Jilin,China,3Collegeof AnimalScienceandTechnology,JilinAgriculturalUniversity,Changchun,Jilin,China,4JilinEntry-ExitInspectionandQuarantineBureau,Changchun,Jilin,China Abstract Background:Human-likeH3N2influenzaviruseshaverepeatedlybeentransmittedtodomesticpigsindifferentregionsof theworld,butitisstilluncertainwhetheranyofthesevariantscouldbecomeestablishedinpigpopulations.Thefactthat different subtypes of influenza viruses have been detected in pigs makes them an ideal candidate for the genesis of a possible reassortant virus withboth humanand avianorigins. However, thedetermination of whetherpigs canact asa ‘‘mixing vessel’’ for a possible future pandemic virus is still pending an answer. This prompted us to gather the epidemiologicalinformationandinvestigatethegeneticevolutionofswineinfluenzavirusesinJilin,China. Methods:NasopharyngealswabswerecollectedfrompigswithrespiratoryillnessinJilinprovince,ChinafromJuly2007to October2008.AllsampleswerescreenedforinfluenzaAviruses.ThreeH3N2swineinfluenzavirusisolateswereanalyzed geneticallyandphylogenetically. Results:InfluenzasurveillanceofpigsinJilinprovince,ChinarevealedthatH3N2influenzaviruseswereregularlydetected fromdomesticpigsduring2007to2008.PhylogeneticanalysisrevealedthattwodistinguishablegroupsofH3N2influenza viruses were present in pigs: the wholly contemporary human-like H3N2 viruses (represented by the Moscow/10/99-like sublineage)anddouble-reassortantvirusescontaininggenesfromcontemporaryhumanH3N2virusesandavianH5viruses, bothco-circulatinginpigpopulations. Conclusions:Thepresentstudyreportsforthefirsttimethecoexistenceofwhollyh