Relaxin and β-estradiol modulate targeted matrix degradation in specific synovial joint fibrocartilages progesterone prevents matrix loss 英文参考文献.docVIP

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Relaxin and β-estradiol modulate targeted matrix degradation in specific synovial joint fibrocartilages progesterone prevents matrix loss 英文参考文献.doc

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Relaxin and β-estradiol modulate targeted matrix degradation in specific synovial joint fibrocartilages progesterone prevents matrix loss 英文参考文献

Available online /content/8/4/R98 Research article Open Access Vol 8 No 4 Relaxin and β-estradiol modulate targeted matrix degradation in specific synovial joint fibrocartilages: progesterone prevents matrix loss Gihan Hashem, Qin Zhang, Takayuki Hayami, Jean Chen, Wei Wang and Sunil Kapila Department of Orthodontics and Pediatric Dentistry, University of Michigan, 1011 North University Avenue, Ann Arbor, MI 48109-1078, USA Corresponding author: Sunil Kapila, skapila@ Received: 21 Mar 2006 Revisions requested: 10 May 2006 Revisions received: 17 May 2006 Accepted: 25 May 2006 Published: 19 Jun 2006 Arthritis Research Therapy 2006, 8:R98 (doi:10.1186/ar1978) This article is online at: /content/8/4/R98 ? 2006 Hashem et al.; licensee BioMed Central Ltd. This is an open access article distributed under the terms of the Creative Commons Attribution License (/licenses/by/2.0), which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited. Abstract Relaxin, a 6-kDa polypeptide hormone, is a potent mediator of matrix turnover and contributes to the loss of collagen and tissues, subcutaneous implantation of osmotic pumps containing relaxin (23.3 μg/kg) or saline. Tissues were retrieved 4 days later and analyzed for GAG and collagen. Serum relaxin levels were assayed using enzyme-linked immunosorbent assay. Relaxin administration resulted in a 30-fold significant (p 0.0001) increase in median levels (range, approximately 38 to 58 pg/ml) of systemic relaxin. β-estradiol, relaxin, or β-estradiol + relaxin caused a significant loss of GAGs and collagen from the pubic symphysis and TMJ disc and of collagen from articular cartilage but not from the knee meniscus. Progesterone prevented relaxin- or β-estradiol-mediated loss of these molecules. The loss of GAGs and collagen caused by β-estradiol, relaxin, or β- estradiol + relaxin varied between tissues a