Relevance of Stereotyped B-Cell Receptors in the Context of the Molecular, Cytogenetic and Clinical Features of Chronic Lymphocytic Leukemia 英文参考文献.docVIP

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Relevance of Stereotyped B-Cell Receptors in the Context of the Molecular, Cytogenetic and Clinical Features of Chronic Lymphocytic Leukemia 英文参考文献.doc

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Relevance of Stereotyped B-Cell Receptors in the Context of the Molecular, Cytogenetic and Clinical Features of Chronic Lymphocytic Leukemia 英文参考文献

RelevanceofStereotypedB-CellReceptorsinthe ContextoftheMolecular,CytogeneticandClinical FeaturesofChronicLymphocyticLeukemia FrancescoMaura1.,GiovannaCutrona2.,SoniaFabris1,MonicaColombo3,GiacomoTuana1 ,Luca Agnelli1,SerenaMatis3,MartaLionetti1,MassimoGentile4,AnnaGraziaRecchia4,FrancescoDi Raimondo5,CaterinaMusolino6,FiorellaIlariucci7,NicolaDiRenzo8,EmanuelaPesce9,StefanoMolica10, MassimoFederico9,AgostinoCortelezzi1,FortunatoMorabito4,ManlioFerrarini3,AntoninoNeri1* 1Ematologia1CTMO,FondazioneIRCCSCa’GrandaOspedaleMaggiorePoliclinicoandDipartimentodiScienzeMediche,Universita`diMilano,Milan,Italy,2Diagnostica Molecolare, Dipartimento di Tecnologie Diagnostiche Avanzate, Istituto Nazionale per la Ricerca sul Cancro, Genova, Italy, 3Divisione di Oncologia Medica C, Istituto NazionaleperlaRicercasulCancroandDipartimentodiOncologia,BiologiaeGenetica,Universita`degliStudidiGenova,Genova,Italy,4DipartimentodiOncoematologia, AziendaOspedalieradiCosenza,Cosenza,Italy,5SezionediEmatologia,OncologiaePatologiaGenerale,DipartimentodiBioMedicinaClinicaeMolecolare,Ospedale Ferrarotto,Catania,Italy,6DivisionediEmatologia,Universita` diMessina,Messina,Italy,7Unita` diEmatologia,OspedaleSantaMariaNuova,ReggioEmilia,Italy,8Unita` Operativa di Ematologia e Trapianto di Cellule Staminali, Ospedale Vito Fazzi, Lecce, Italy, 9Universita` degli Studi di Modena e Reggio Emilia - Oncologia Medica Policlinico,Modena,Italy,10Unita` OperativadiOncologia,AziendaOspedalieraPuglieseCiaccio,Catanzaro,Italy Abstract HighlyhomologousB-cellreceptors,characterizedbynon-randomcombinationsofimmunoglobulinheavy-chainvariable (IGHV) genes and heavy-chain complementarity determining region-3 (HCDR3), are expressed in a recurrent fraction of patients affected by chronic lymphocytic leukemia (CLL). We investigated the IGHV status of 1131 productive IG rearrangementsfromapanelof1126CLLpatientsfromamulticenterItalianstudygroup,andcorrelatedthepresenceand classofHCDR3stereotypedsubsetswiththemajorcyt