Relationship between Resting Pulse Rate and Lipid Metabolic Dysfunctions in Chinese Adults Living in Rural Areas 英文参考文献.docVIP

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Relationship between Resting Pulse Rate and Lipid Metabolic Dysfunctions in Chinese Adults Living in Rural Areas 英文参考文献.doc

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Relationship between Resting Pulse Rate and Lipid Metabolic Dysfunctions in Chinese Adults Living in Rural Areas 英文参考文献

RelationshipbetweenRestingPulseRateandLipid MetabolicDysfunctionsinChineseAdultsLivinginRural Areas Chong-jianWang1,2*,Yu-qianLi3,Lin-linLi1,LingWang1,Jing-zhiZhao4,Ai-guoYou5,Yi-ruiGuo1 ,Wen- jieLi1 1DepartmentofEpidemiologyandBiostatistics,CollegeofPublicHealth,ZhengzhouUniversity,Zhengzhou,Henan,PRChina,2ResearchCentre,CHUSainte-Justine, Montreal,Quebec,Canada,3DepartmentofClinicalPharmacology,SchoolofPharmaceuticalScience,ZhengzhouUniversity,Zhengzhou,Henan,PRChina,4Department ofEndocrinology,MilitaryHospitalofHenanProvince,Zhengzhou,Henan,PRChina,5DepartmentofDiseaseControlandPrevention,HenanProvincialCenterforDisease ControlandPrevention,Zhengzhou,Henan,PRChina Abstract Background:Restingpulseratehasbeenobservedtobeassociatedwithcardiovasculardiseases.However,itsassociation withlipidmetabolicdysfunctionsremainsunclear,especiallyrestingpulserateasanindicatorforidentifyingtheriskoflipid metabolic dysfunctions. The purpose of this study was to examine the association between resting pulse rate and lipid metabolicdysfunctions,andthenevaluatethefeasibilityofrestingpulserateasanindicatorforscreeningtheriskoflipid metabolicdysfunctions. Methods:Across-sectionalsurveywasperformed,and16,926subjectswereincludedinthisstudyfromruralcommunity residentsaged35–78years.Restingpulserateandrelevantcovariateswerecollectedfromastandardquestionnaire.The fasting blood samples were collected and measured for lipid profile. Predictive performance was analyzed by receiver operatingcharacteristic(ROC)curve. Results: A significant correlation was observed between resting pulse rate and TC (r=0.102, P=0.001), TG (r =0.182, P=0.001),anddyslipidemia (r=0.037,P=0.008).Inthemultivariatemodels, theadjustedoddsratios forhypercholester- olemia (from 1.07 to 1.15), hypertriglyceridemia (1.11 to 1.16), low HDL hypercholesterolemia (1.03 to 1.06), high LDL hypercholesterolemia (0.92 to 1.14), and dyslipidemia (1.04 to 1.07) were positively increased across quartiles of resting pulserate(Pf