Relationship of metabolic syndrome and its components with -844 GA and HindIII CG PAI-1 gene polymorphisms in Mexican children 英文参考文献.docVIP

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Relationship of metabolic syndrome and its components with -844 GA and HindIII CG PAI-1 gene polymorphisms in Mexican children 英文参考文献.doc

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Relationship of metabolic syndrome and its components with -844 GA and HindIII CG PAI-1 gene polymorphisms in Mexican children 英文参考文献

DelaCruz-Mossoetal.BMCPediatrics2012,12:41 /1471-2431/12/41 RESEARCH ARTICLE OpenAccess Relationshipofmetabolicsyndromeandits componentswith-844G/AandHindIIIC/GPAI-1 genepolymorphismsinMexicanchildren UlisesDelaCruz-Mosso1,JoséFMu?oz-Valle2,LorenzoSalgado-Goytia1,AdriánGarcía-Carreón1, BereniceIllades-Aguiar1,EduardoCasta?eda-Saucedo1andIselaParra-Rojas1* Abstract Background:Severalassociationstudieshaveshownthat-844G/AandHindIIIC/GPAI-1polymorphismsare relatedwithincreaseofPAI-1levels,obesity,insulinresistance,glucoseintolerance,hypertensionanddyslipidemia, whicharecomponentsofmetabolicsyndrome.Theaimofthisstudywastoanalyzethealleleandgenotype frequenciesofthesepolymorphismsinPAI-1geneanditsassociationwithmetabolicsyndromeandits componentsinasampleofMexicanmestizochildren. Methods:Thisstudyincluded100childrenwithanagerangebetween6-11yearsdividedintwogroups:a)48 childrendiagnosedwithmetabolicsyndromeandb)52childrenmetabolicallyhealthywithoutanyclinicaland biochemicalalteration.Metabolicsyndromewasdefinedasthepresenceofthreeormoreofthefollowingcriteria: fastingglucoselevels≥100mg/dL,triglycerides≥150mg/dL,HDL-cholesterol40mg/dL,obesityBMI≥95th percentile,systolicbloodpressure(SBP)anddiastolicbloodpressure(DBP)≥95th percentileandinsulinresistance HOMA-IR≥2.4.The-844G/AandHindIIIC/GPAI-1polymorphismswereanalyzedbyPCR-RFLP. Results:Forthe-844G/Apolymorphism,theG/Agenotype(OR=2.79;95%CI,1.11-7.08;p=0.015)andtheA allele(OR=2.2;95%CI,1.10-4.43;p=0.015)wereassociatedwithmetabolicsyndrome.The-844G/AandA/A genotypeswereassociatedwithincreaseinplasmatriglycerideslevels(OR=2.6;95%CI,1.16to6.04;p=0.02), decreaseinplasmaHDL-cholesterollevels(OR=2.4;95%CI,1.06to5.42;p=0.03)andobesity(OR=2.6;95%CI, 1.17-5.92;p=0.01).TheC/GandG/GgenotypesoftheHindIIIC/Gpolymorphismcontributedtoasignificant increaseinplasmatotalcholesterollevels(179vs.165mg/dL;p=0.02)incomparisonwithC/Cgenotype. Conclusions:The-844G/APAI-1polymorphismisrelatedwiththeriskofdevelopingmetabolicsyndrome,obesity