Repeated Methamphetamine Administration Differentially Alters Fos Expression in Caudate-Putamen Patch and Matrix Compartments and Nucleus Accumbens 英文参考文献.docVIP

RepeatedMethamphetamineAdministration DifferentiallyAltersFosExpressioninCaudate-Putamen PatchandMatrixCompartmentsandNucleus Accumbens JakubP.Jedynak2*,CourtneyM.Cameron1,TerryE.Robinson1,2 1Department of Psychology, University of Michigan, Ann Arbor, Michigan, United States of America, 2Neuroscience Program, University of Michigan, Ann Arbor, Michigan,UnitedStatesofAmerica Abstract Background: The repeated administration of psychostimulant drugs produces a persistent and long-lasting increase (‘‘sensitization’’)intheirpsychomotoreffects,whichisthoughttobeduetochangesintheneuralcircuitrythatmediate these behaviors. One index of neuronal activation used to identify brain regions altered by repeated exposure to drugs involvestheirabilitytoinduceimmediateearlygenes,suchasc-fos.Numerousreportshavedemonstratedthatpastdrug experiencealterstheabilityofdrugstoinducec-fosinthestriatum,butveryfewhaveexaminedFosproteinexpressionin thetwomajorcompartmentsinthestriatum—theso-calledpatch/striosomeandmatrix. Methodology/Principal Findings: In the present study, we used immunohistochemistry to investigate the effects of pretreatmentwithmethamphetamineontheabilityofasubsequentmethamphetaminechallengetoinduceFosprotein expressioninthepatchandmatrixcompartmentsofthedorsolateralanddorsomedialcaudate-putamenandintheventral striatum(nucleusaccumbens).Animalspretreatedwithmethamphetaminedevelopedrobustpsychomotorsensitization.A methamphetamine challenge increased the number of Fos-positive cells in all areas of the dorsal and ventral striatum. However,methamphetaminechallengeinducedFosexpressioninmorecellsinthepatchthaninthematrixcompartment inthedorsolateralanddorsomedialcaudate-putamen.Furthermore,pastexperiencewithmethamphetamineincreasedthe numberofmethamphetamine-inducedFospositivecellsinthepatchcompartmentofthedorsalcaudateputamen,butnot inthematrixorinthecoreorshellofthenucleusaccumbens. Conclusions/Significance: These data suggest that drug-induced alterations in the patch comp