Repeated Assessment of Exploration and Novelty Seeking in the Human Behavioral Pattern Monitor in Bipolar Disorder Patients and Healthy Individuals 英文参考文献.docVIP

RepeatedAssessmentofExplorationandNovelty SeekingintheHumanBehavioralPatternMonitorin BipolarDisorderPatientsandHealthyIndividuals ArpiMinassian*,BrookL.Henry,JaredW.Young,VirginiaMasten,MarkA.Geyer,WilliamPerry DepartmentofPsychiatry,UniversityofCaliforniaSanDiego,SanDiego,California,UnitedStatesofAmerica Abstract Background:Explorationandnoveltyseekingarecross-speciesadaptivebehaviorsthataredysregulatedinbipolardisorder (BD)andarecriticalfeaturesoftheillness.Whilethesebehaviorshavebeenextensivelyquantifiedinanimals,multivariate humanparadigmsofexplorationarelacking.ThehumanBehavioralPatternMonitor(hBPM),ahumanversionoftheanimal open field, identified a signature pattern of hyper-exploration in manic BD patients, but whether exploratory behavior changeswithtreatmentisunknown.TheobjectiveofthisstudywastoassessthesensitivityofthehBPMtochangesin manicsymptoms,anecessarysteptowardselucidatingtheneurobiologyunderlyingBD. Methodology and Principal Findings: Twelve acutely hospitalized manic BD subjects and 21 healthy volunteers were testedinthehBPMoverthreesessions;allsubjectswereretestedoneweekaftertheirfirstsessionandtwoweeksaftertheir second session. Motor activity, spatial and entropic (degree of unpredictability) patterns of exploration, and interactions with novel objects were quantified. Manic BD patients demonstrated greater motor activity, extensive and more unpredictable patterns of exploration, and more object interactions than healthy volunteers during all three sessions. Exploration and novelty-seeking slightly decreased in manic BD subjects over the three sessions as their symptoms responded to treatment, but never to the level of healthy volunteers. Among healthy volunteers, exploration did not significantlydecreaseovertime,andhBPMmeasureswerehighlycorrelatedbetweensessions. Conclusions/Significance: Manic BD patients showed a modest reduction in symptoms yet still demonstrated hyper- explorationandnoveltyseekinginthehBPM,suggestingthattheseillnessfeatur