Response Monitoring in De Novo Patients with Parkinsons Disease 英文参考文献.docVIP

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Response Monitoring in De Novo Patients with Parkinsons Disease 英文参考文献.doc

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Response Monitoring in De Novo Patients with Parkinsons Disease 英文参考文献

ResponseMonitoringinDeNovoPatientswith Parkinson’sDisease RitaWillemssen1*,ThomasMu¨ller2,MichaelSchwarz3,MichaelFalkenstein1,ChristianBeste1,4 1Leibniz Research Centre for Working Environment and Human Factors, WHO Collaborating Research Centre Dortmund, Dortmund, Germany, 2Department of Neurology, St. Joseph Hospital, Klinik-Weissensee, Berlin, Germany, 3Department of Neurology, Klinikum Dortmund, Dortmund, Germany, 4Institute for Cognitive Neuroscience,Biopsychology,Ruhr-UniversityBochum,Bochum,Germany Abstract Background:Parkinson’sdisease(PD)isaccompaniedbydysfunctionsinavarietyofcognitiveprocesses.Oneoftheseis errorprocessing,whichdependsuponphasicdecreasesofmedialprefrontaldopaminergicactivity.Untilnow,thereisno studyevaluatingtheseprocessesinnewlydiagnosed,untreatedpatientswithPD(‘‘denovoPD’’). Methodology/PrincipalFindings:Herewereportlargechangesinperformancemonitoringprocessesusingevent-related potentials(ERPs)indenovoPD-patients.Theresultssuggestthatincreasesinmedialfrontaldopaminergicactivityafteran error (Ne) are decreased, relative to age-matched controls. In contrast, neurophysiological processes reflecting general motorresponsemonitoring(Nc)areenhancedindenovopatients. Conclusions/Significance:ItmaybehypothesizedthattheNc-increaseisatcostsofdopaminergicactivityafteranerror;on a functional level errors may not always be detected and correct responses sometimes be misinterpreted as errors. This pattern differs from studies examining patients with a longer history of PD and may reflect compensatory processes, frequentlyoccurringinpre-manifeststagesofPD.FromaclinicalpointofviewtheclearlyattenuatedNeinthedenovoPD patientsmayproveausefuladditionaltoolfortheearlydiagnosisofbasalgangliadysfunctioninPD. Citation:WillemssenR,Mu¨llerT,SchwarzM,FalkensteinM,BesteC(2009)ResponseMonitoringinDeNovoPatientswithParkinson’sDisease.PLoSONE4(3): e4898.doi:10.1371/journal.pone.0004898 Editor:Andre′ Aleman,UniversityofGroningen,Netherlands ReceivedDecember10,2008;Accep