Response Surface Modeling and Optimization of Accelerated Solvent Extraction of Four Lignans from Fructus Schisandrae 英文参考文献.docVIP

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Response Surface Modeling and Optimization of Accelerated Solvent Extraction of Four Lignans from Fructus Schisandrae 英文参考文献.doc

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Response Surface Modeling and Optimization of Accelerated Solvent Extraction of Four Lignans from Fructus Schisandrae 英文参考文献

Molecules 2012, 17, 3618-3629; doi:10.3390/moleculeOPEN ACCESS molecules ISSN 1420-3049 /journal/molecules Article Response Surface Modeling and Optimization of Accelerated Solvent Extraction of Four Lignans from Fructus Schisandrae Li-Chun Zhao 1,2, Ying He 1, Xin Deng 1, Geng-Liang Yang 2, Wei Li 3, Jian Liang 1,* and Qian-Li Tang 4,* 1 Affiliated Ruikang Hospital of Guangxi University of Chinese Medicine, Nanning 530011, China 2 College of Pharmacy, Hebei University, Baoding 071002, China 3 College of Chinese Medicinal Materials, Jilin Agricultural University, Changchun 130118, China 4 Department of Scientific Research, Guangxi University of Chinese Medicine, Nanning 530011, China * Authors to whom correspondence should be addressed; E-Mails: ljruikang@126.com (J.L.); htmgx@163.com (Q.-L.T.); Tel.: +86-771-218-8589 (J.L.); Fax: +86-771-233-5098(J.L.). Received: 6 February 2012; in revised form: 6 March 2012 / Accepted: 15 March 2012 / Published: 23 March 2012 Abstract: A new method based on accelerated solvent extraction (ASE) combined with response surface methodology (RSM) modeling and optimization has been developed for the extraction of four lignans in Fructus Schisandrae (the fruits of Schisandra chinensis Baill). The RSM method, based on a three level and three variable Box-Behnken design (BBD), was employed to obtain the optimal combination of extraction condition. In brief, the lignans schizandrin, schisandrol B, deoxyschizandrin and schisandrin B were optimally extracted with 87% ethanol as extraction solvent, extraction temperature of 160 °C, static extraction time of 10 min, extraction pressure of 1,500 psi, flush volume of 60% and one extraction cycle. The 3D response surface plot and the contour plot derived from the mathematical models were applied to determine the optimal conditions. Under the above conditions, the experimental value of four lignans was 14.72 mg/g, which