Response of tibialis anterior tendon to a chronic exposure of stretch-shortening cycles age effects 英文参考文献.docVIP

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Response of tibialis anterior tendon to a chronic exposure of stretch-shortening cycles age effects 英文参考文献.doc

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Response of tibialis anterior tendon to a chronic exposure of stretch-shortening cycles age effects 英文参考文献

BioMedical Engineering OnLine BioMedCentral Research Open Access Response of tibialis anterior tendon to a chronic exposure of stretch-shortening cycles: age effects James S Ensey, Melinda S Hollander, John Z Wu, Michael L Kashon, Brent B Baker and Robert G Cutlip* Address: National Institute for Occupational Safety and Health (NIOSH), Health Effects Laboratory Division, Morgantown, West Virginia 26505, USA Email: James S Ensey - jensey@; Melinda S Hollander - mindysue1@; John Z Wu - jwu@; Michael L Kashon - mkashon@; Brent B Baker - bbaker@; Robert G Cutlip* - rgc8@ * Corresponding author Published: 29 June 2009 Received: 16 December 2008 Accepted: 29 June 2009 BioMedical Engineering OnLine 2009, 8:12 doi:10.1186/1475-925X-8-12 This article is available from: /content/8/1/12 ? 2009 Ensey et al; licensee BioMed Central Ltd. This is an Open Access article distributed under the terms of the Creative Commons Attribution License (/licenses/by/2.0), which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited. Abstract Background: The purpose of the current study was to investigate the effects of aging on tendon response to repetitive exposures of stretch-shortening cycles (SSCs). Methods: The left hind limb from young (3 mo, N = 4) and old (30 mo, N = 9) male Fisher 344 × Brown Norway rats were exposed to 80 maximal SSCs (60 deg/s, 50 deg range of motion) 3x/week for 4.5 weeks in vivo. After the last exposure, tendons from the tibialis anterior muscle were isolated, stored at -80°C, and then tested using a micro-mechanical testing machine. Deformation of each tendon was evaluated using both relative grip-to-grip displacements and reference marks via a video system. Results: At failure, the young control tendons had higher strain magnitude than the young exposed (p 0.01) and the old control tendons (p .0001). Total load at inflection was affected by age only (p 0.01).