Resting Energy Expenditure in Young Adults Born Preterm—The Helsinki Study of Very Low Birth Weight Adults 英文参考文献.docVIP

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Resting Energy Expenditure in Young Adults Born Preterm—The Helsinki Study of Very Low Birth Weight Adults 英文参考文献.doc

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Resting Energy Expenditure in Young Adults Born Preterm—The Helsinki Study of Very Low Birth Weight Adults 英文参考文献

RestingEnergyExpenditureinYoungAdultsBorn Preterm—TheHelsinkiStudyofVeryLowBirthWeight Adults MarikaSipola-Leppa¨nen1,2,PetteriHovi3,4,StureAndersson4,KaroliinaWehkalampi3,4 ,Marja Va¨a¨ra¨sma¨ki5,6,SonjaStrang-Karlsson3,4,Anna-LiisaJa¨rvenpa¨a¨4,OutiMa¨kitie4,JohanG.Eriksson3,7,8,9,10, EeroKajantie3,4 * 1Diabetes Prevention Unit, Department of Chronic Disease Prevention, National Institute for Health and Welfare, Oulu, Finland, 2Department of Pediatrics and Adolescence,UniversityofOulu,Oulu,Finland,3DiabetesPreventionUnit,DepartmentofChronicDiseasePrevention,NationalInstituteforHealthandWelfare,Helsinki, Finland, 4Hospital for Children and Adolescents, Helsinki University Central Hospital and University of Helsinki, Helsinki, Finland, 5Department of Obstetrics and Gynaecology, Oulu University Hospital, Oulu, Finland, 6Department of Children, Young People and Families, National Institute for Health and Welfare, Oulu, Finland, 7DepartmentofGeneralPracticeandPrimaryHealthCare,UniversityofHelsinki,HelsinkiFinland,8VasaCentralHospital,Vasa,Finland,9Folkha¨lsan ResearchInstitute, Helsinki,Finland,10UnitofGeneralPractice,HelsinkiUniversityCentralHospital,UniversityofHelsinki,Helsinki,Finland Abstract Background: Adults born preterm with very low birth weight (VLBW; ,1500g) have higher levels of cardiovascular and metabolic risk factors than their counterparts born at term. Resting energy expenditure (REE) could be one factor contributingto,orprotectingfrom,theserisks.WestudiedtheeffectsofprematurebirthwithVLBWonREE. Methodology/Principal Findings: We used indirect calorimetry to measure REE and dual x-ray absorptiometry (DXA) to measure lean body mass (LBM) in 116 VLBW and in 118 term-born control individuals (mean age: 22.5 years, SD 2.2) participatinginacohortstudy.ComparedwithcontrolsVLBWadultshad6.3%lowerREE(95%CI3.2,9.3)adjustedforage and sex, but 6.1% higher REE/LBM ratio (95% CI 3.4, 8.6). These differences remained similar when further adjusted for parent