Ring-substituted 4-Hydroxy-1H-quinolin-2-ones Preparation and Biological Activity 英文参考文献.docVIP

Molecules 2009, 14, 1145-1159; doi:10.3390/moleculeOPEN ACCESS molecules ISSN 1420-3049 /journal/molecules Article Ring-substituted 4-Hydroxy-1H-quinolin-2-ones: Preparation and Biological Activity ? Josef Jampilek 1,2,*, Robert Musiol 3, Matus Pesko 4, Katarina Kralova 4, Marcela Vejsova 5, James Carroll 6, Aidan Coffey 6, Jacek Finster 3, Dominik Tabak 3, Halina Niedbala 3, Violetta Kozik 3, Jaroslaw Polanski 3, Jozef Csollei 2 and Jiri Dohnal 1,2 1 Zentiva k.s., U kabelovny 130, 102 37 Prague 10, Czech Republic 2 Department of Chemical Drugs, Faculty of Pharmacy, University of Veterinary and Pharmaceutical Sciences, Palackeho 1/3, 61242 Brno, Czech Republic 3 Institute of Chemistry, University of Silesia, Szkolna 9, 40007 Katowice, Poland; E-mail: robert.musiol@.pl (R.M.), polanski@.pl (J.P.) 4 Institute of Chemistry, Faculty of Natural Sciences, Comenius University, Mlynska dolina Ch-2, 84215 Bratislava, Slovakia; E-mail: kralova@fns.uniba.sk (M.P.) 5 Department of Biological and Medical Sciences, Faculty of Pharmacy in Hradec Kralove, Charles University in Prague, Heyrovskeho 1203, 500 05 Hradec Kralove, Czech Republic; E-mail: marcela.vejsova@faf.cuni.cz (M.V.) 6 Department of Biological Sciences, Cork Institute of Technology, Bishopstown, Cork, Ireland; E-mail: james.carroll@cit.ie (J.C.), aidan.coffey@cit.ie (A.C.) ? Preliminary results were presented at The Twelfth Electronic Conference on Synthetic Organic Chemistry (ECSOC-12, http://www.usc.es/congresos/ecsoc/12/ECSOC12.htm), November 1-30, 2008 (paper C0012). * Author to whom correspondence should be addressed; E-mail: josef.jampilek@zentiva.cz; Tel.: +42026724695; Fax: +420272701331. Received: 4 February 2009; in revised form: 3 March 2009 / Accepted: 11 March 2009 / Published: 13 March 2009 Abstract: In the study, a series of twelve ring-substituted 4-hydroxy-1H-quinolin-2-one derivatives were prepared. The procedures for synthesis of the