Revised NMR data for Incartine an Alkaloid from Galanthus elwesii 英文参考文献.docVIP

Molecules 2007, 12, 1430-1435 molecules ISSN 1420-3049 ? 2007 by MDPI /molecules Communication Revised NMR data for Incartine: an Alkaloid from Galanthus elwesii Strahil Berkov 1, Ricardo Reyes-Chilpa 2, Carles Codina 1, Francesc Viladomat 1 and Jaume Bastida 1,* 1 Departament de Productes Naturals, Biologia Vegetal i Edafologia, Facultat de Farmàcia, Universitat de Barcelona, Av. Diagonal 643, 08028 Barcelona, Spain 2 Instituto de Química, Universidad Nacional Autónoma de México, Ciudad Universitaria, Coyoacán 04510, México DF, México * Author to whom correspondence should be addressed; E-mail: jaumebastida@; Phone: (+34) 934024493 Received: 18 June 2007; in revised form: 10 July 2007 / Accepted: 10 July 2007 / Published: 12 July 2007 Abstract: Phytochemical studies on Galanthus elwesii resulted in the isolation of five alkaloids: incartine, hordenine, hippeastrine, 8-O-demethylhomolycorine and lycorine. The NMR data given previously for incartine were revised and completed by two-dimensional 1H-1H and 1H-13C chemical shift correlation experiments. In vitro studies on the bioactivity of incartine were carried out. Keywords: Galanthus elwesii; Amaryllidaceae alkaloids; incartine; NMR. Introduction Galanthus elwesii (snow drop) is a small bulbous plant distributed throughout South-Eastern European countries and Euro-Asia [1], which has been cultivated for its elegant flowers. Earlier investigations in Galanthus elwesii have resulted in the isolation of a large variety of Amaryllidaceae alkaloids [2-4]. Many of these compounds have been found to exhibit among others, strong acetylcholinesterase inhibitory, cytotoxic and antiviral activities [5].  Molecules 2007, 12 1431 As part of our ongoing studies on the Galanthus species, we report on the isolation, structural elucidation of incartine (1) hordenine (2), lycorine (3), 8-O-demethylhomolycorine (4) and hippeastrine