Retroviruses at a glance 英文参考文献.docVIP

/2000/1/3/reports/4015.1 Meeting report Retroviruses at a glance Cecile Voisset* and Mariam Andrawiss? Addresses: *Wohl Virion Centre and ?Department of Immunology, Windeyer Institute, University College London, 46 Cleveland Street, London W1P 6DB, UK. E-mail: m.andrawiss@ucl.ac.uk, c.voisset@ucl.ac.uk Published: 15 September 2000 GenomeBiology 2000, 1(3):reports4015.1–4015.4 The electronic version of this article is the complete one and can be found online at /2000/1/3/reports/4015 ? GenomeB (Print ISSN 1465-6906; Online ISSN 1465-6914) structure is composed of long terminal repeat (LTR) A report from the Cold Spring Harbor Laboratory 2000 conference on Retroviruses, Cold Spring Harbor, May 23-28, 2000. sequences located at each end of the integrated genome, sur- rounding gag, PR, pol and env coding genes. Proviral DNA transcription and translation are performed by the cellular machinery. After assembly of RNA and viral proteins, parti- cles bud from the plasma membrane and are further Gaining better knowledge and understanding of retroviral genomes, life cycles and interactions within host cell machin- ery is a major requirement for anti-retroviral therapies. The matured by protease cleavage of Gag polyproteins. The transmembrane subunit of the viral envelope protein was traditionally thought to contain all the domains required International Retroviruses 2000 conference assembled reports describing new discoveries on fundamental steps of retrovirus biology. We have focused our report on the areas which seemed to show the most recent developments: the fusion process, entry, assembly-budding-maturation, and also new breakthroughs looking at endogenous retroviruses. Lipid Bilayer SU TM MA PR Retroviral particles possess a lipid bilayer envelope derived from the plasma membrane of the host cell. Env glycopro- teins are localised on the envelope of the retrovira