Results of a phase-III randomized, masked, placebo-controlled trial of recombinant human interleukin-11 (rhIL-11) in the treatment of subjects with active rheumatoid arthritis 英文参考文献.docVIP

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Results of a phase-III randomized, masked, placebo-controlled trial of recombinant human interleukin-11 (rhIL-11) in the treatment of subjects with active rheumatoid arthritis 英文参考文献.doc

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Results of a phase-III randomized, masked, placebo-controlled trial of recombinant human interleukin-11 (rhIL-11) in the treatment of subjects with active rheumatoid arthritis 英文参考文献

Available online /content/3/4/247 Primary research Results of a phase-I/II randomized, masked, placebo-controlled trial of recombinant human interleukin-11 (rhIL-11) in the treatment of subjects with active rheumatoid arthritis Larry Moreland*, Ron Gugliotti?, Kevin King?, Walter Chase§, Michael Weisman?, Thomas Greco**, Rose Fife??, Joseph Korn??, Robert Simms??, John Tesser§§, Jan Hillson??, Jacques Caldwell***, Thomas Schnitzer???, David Lyons? and Ullrich Schwertschlag? *Department of Medicine, University of Alabama at Birmingham, Birmingham, AL, USA ?ClinTrials Research Inc., Cary, NC, USA ?Genetics Institute, Inc., Cambridge, MA, USA §1301 W 38th Street, Suite 609, Austin, TX, USA ?University of California, San Diego, La Jolla, CA, USA **133 Scovill Street, Suite 306, Waterbury, CT 06706, USA ??Office of the Dean, Indiana University School of Medicine, Indianapolis, IN, USA ??Arthritis Center, Boston University School of Medicine, Boston, MA, USA §§Phoenix Center for Clinical Research, Arizona Rheumatology Center, Phoenix, AZ, USA ??Virginia Mason Research Center, Seattle, WA, USA ***Florida Arthritis Allergy Institute PA, Daytona Beach, FL, USA ???Northwestern University, Office of Clinical Research, Chicago, IL, USA Correspondence: Larry Moreland, MD, University of Alabama at Birmingham, 1717 6th Avenue S, SRC 068, Birmingham, AL 35294, USA. Tel: +1 (205) 934 7727; fax: +1 (205) 975 5554; e-mail: larry.moreland@ Received: 15 December 2000 Revisions requested: 6 February 2001 Revisions received: 23 March 2001 Accepted: 26 March 2001 Arthritis Res 2001, 3:247–252 This article may contain supplementary data which can only be found online at /content/3/4/247 ? 2001 Moreland et al, licensee BioMed Central Ltd Published: 10 April 2001 (Print ISSN 1465-9905; Online ISSN 1465-9913) Abstract Interleukin-11 (IL-11) is a pleiotropic cytokine that regulates the growth and development of hematopoietic stem cells and decreases the proinflammatory