Results of Genome-Wide Analyses on Neurodevelopmental Phenotypes at Four-Year Follow-Up following Cardiac Surgery in Infancy 英文参考文献.docVIP

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Results of Genome-Wide Analyses on Neurodevelopmental Phenotypes at Four-Year Follow-Up following Cardiac Surgery in Infancy 英文参考文献.doc

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Results of Genome-Wide Analyses on Neurodevelopmental Phenotypes at Four-Year Follow-Up following Cardiac Surgery in Infancy 英文参考文献

ResultsofGenome-WideAnalyseson NeurodevelopmentalPhenotypesatFour-YearFollow- UpfollowingCardiacSurgeryinInfancy DanielS.Kim1,2,IanB.Stanaway2,RamakrishnanRajagopalan1,JudyC.Bernbaum3,CynthiaB.Solot4, NancyBurnham5,ElaineH.Zackai6,RobertR.Clancy7,SusanC.Nicolson8,MarshaGerdes9, DeborahA.Nickerson2,HakonHakonarson10,11,J.WilliamGaynor5,GailP.Jarvik1,2* 1DepartmentofMedicine,DivisionofMedicalGenetics,UniversityofWashingtonSchoolofMedicine,Seattle,Washington,UnitedStatesofAmerica,2Departmentof GenomeSciences,UniversityofWashingtonSchoolofMedicine,Seattle,Washington,UnitedStatesofAmerica, 3DivisionofGeneralPediatrics,Children’sHospitalof Philadelphia,Philadelphia,Pennsylvania,UnitedStatesofAmerica,4CenterforChildhoodCommunication,Children’sHospitalofPhiladelphia,Philadelphia,Pennsylvania, United States of America, 5Division of Cardiothoracic Surgery, Children’s Hospital of Philadelphia, Philadelphia, Pennsylvania, United States of America, 6Division of Genetics, Children’s Hospital of Philadelphia, Philadelphia, Pennsylvania, United States of America, 7Division of Neurology, Children’s Hospital of Philadelphia, Philadelphia,Pennsylvania,UnitedStatesofAmerica,8DivisionofCardiothoracicAnesthesiology,Children’sHospitalofPhiladelphia,Philadelphia,Pennsylvania,United StatesofAmerica,9DivisionofPsychology,Children’sHospitalofPhiladelphia,Philadelphia,Pennsylvania,UnitedStatesofAmerica, 10CenterforAppliedGenomics, Children’s Hospital of Philadelphia, Philadelphia, Pennsylvania, United States of America, 11Department of Pediatrics, University of Pennsylvania School of Medicine, Philadelphia,Pennsylvania,UnitedStatesofAmerica Abstract Background: Adverse neurodevelopmentalsequelaearereportedamongchildren whoundergo earlycardiacsurgery to repaircongenitalheartdefects(CHD).APOEgenotypehaspreviouslybeendeterminedtocontributetothepredictionof these outcomes. Understanding further genetic causes for the development of poor neurobehavioral outcomes should enhancepa