Resveratrol An Antiaging Drug with Potential Therapeutic Applications in Treating Diseases 英文参考文献.docVIP
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Resveratrol An Antiaging Drug with Potential Therapeutic Applications in Treating Diseases 英文参考文献
Pharmaceuticals 2009, 2, 194-205; doi:10.3390/ph2030194
OPEN ACCESS
pharmaceuticals
ISSN 1424-8247
/journal/pharmaceuticals
Review
Resveratrol: An Antiaging Drug with Potential Therapeutic
Applications in Treating Diseases
Antoni Camins 1,*, Felix Junyent 1, Ester Verdaguer 1, Carlos Beas-Zarate 2, Argelia E.
Rojas-Mayorquín 3, Daniel Ortu?o-Sahagún 4 and Mercè Pallàs 1
1
Unitat de Farmacologia i Farmacognòsia i Institut de Biomedicina (IBUB), Centro de Investigación
de Biomedicina en Red de Enfermedades Neurodegenerativas (CIBERNED), Facultat de Farmàcia,
Universitat de Barcelona, Nucli Universitari de Pedralbes, Av. Joan XXIII s/n 08028 Barcelona,
Spain
2
Departamento de Biología Celular y Molecular, CUCBA, Universidad de Guadalajara, División de
Neurociencias, Centro de Investigación Biomédica de Occidente, IMSS, Sierra Mojada 800, Col.
Independencia, Guadalajara, Jalisco 44340, Mexico
3
UMR 975 INSERM, Thérapeutique Expérimentale de la neurodégénérescence, Centre de recherche
de lInstitut du cerveau et de la moelle épiniére (CRICM), Université Pierre et Marie Curie, H?pital
de la Salpêtrière, 47 bld de lH?pital, 75651 Paris Cedex 13, Paris, France
4
Laboratorio de Desarrollo y Regeneración Neural, Instituto de Neurobiología, Departamento de
Biología Celular y Molecular, C.U.C.B.A, Universidad de Guadalajara, Guadalajara, Jalisco,
México
* Author to whom correspondence should be addressed; E-Mail: camins@.
Received: 5 November 2009; in revised form: 2 December 2009 / Accepted: 10 December 2009 /
Published: 15 December 2009
Abstract: The prevention of aging is one of the most fascinating areas in biomedicine. The
first step in the development of effective drugs for aging prevention is a knowledge of the
biochemical pathways responsible for the cellular aging process. In this context it seems
clear that free radicals play a key role in the aging process. However, in recent years it has
been demonstrated that the families of enzymes calle
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