Respiratory Infections by HMPV and RSV Are Clinically Indistinguishable but Induce Different Host Response in Aged Individuals 英文参考文献.docVIP

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Respiratory Infections by HMPV and RSV Are Clinically Indistinguishable but Induce Different Host Response in Aged Individuals 英文参考文献.doc

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Respiratory Infections by HMPV and RSV Are Clinically Indistinguishable but Induce Different Host Response in Aged Individuals 英文参考文献

RespiratoryInfectionsbyHMPVandRSVAreClinically IndistinguishablebutInduceDifferentHostResponsein AgedIndividuals VanessaDitt¤,JessicaLu¨sebrink¤,RamonaLizaTillmann¤,VerenaSchildgen¤,OliverSchildgen*¤ InstituteforVirology,UniversityofBonn,Bonn,Germany Abstract Background:Humanmetapneumovirusandrespiratorysyncytialviruscancausesevererespiratorydiseases,especiallyin infants, young children, and the elderly. So far it remains unclear why infections in the elderly become life threatening despite the presence of neutralizing antibodies in the serum, and to which extent double infections worsen the clinical course. Methods:YoungandagedBALB/c-micewereinfectedwithRSVor/andHMPV.Appearanceofthemicewasobservedduring course of infection. On day 5 p.i. animals were dispatched by cervical dislocation and levels of TNF-a and NF-k B were determined. Results:Theobservationofactivity,weightandappearanceofthedifferentmiceshowednodifferencesamongthetested groups. Despite this, the immunologic response depends on the animals’ age and the virus they were infected with. In young animals, NF-kB levels were elevated if infected with HMPV and HMPV/RSV but remained low in RSV infections, whereasinagedanimalstheoppositewasobserved:solelyRSV-infectedanimalsshowedelevatedlevelsofNF-kB.TNF-a wasslightlyelevatedinHMPV-infectedyoungandoldanimals,butonlyinyounganimalsthiselevationwassignificant. Conclusions: Contrary to other studies, no weight loss or change in activity despite productive lung infection with the differentviruseswereobserved.Thismaybeduetotheweakeranaesthesiaorthelesservolumeofvirussolutionused, leadingtolessstressintheanimals.TheobserveddifferencesinTNF-aandNF-kBelevationleadtotheassumptionthat youngandoldindividualshavedifferentmechanismstoreactagainsttheviruses. Citation:DittV,Lu¨sebrinkJ,TillmannRL,SchildgenV,SchildgenO(2011)RespiratoryInfectionsbyHMPVandRSVAreClinicallyIndistinguishablebutInduce DifferentHostResponseinAgedIndividuals.PLoSONE6(1):e16314.doi:10.1371/journal.pone