Requirement of Male-Specific Dosage Compensation in Drosophila Females—Implications of Early X Chromosome Gene Expression 英文参考文献.docVIP

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Requirement of Male-Specific Dosage Compensation in Drosophila Females—Implications of Early X Chromosome Gene Expression 英文参考文献.doc

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Requirement of Male-Specific Dosage Compensation in Drosophila Females—Implications of Early X Chromosome Gene Expression 英文参考文献

RequirementofMale-SpecificDosageCompensationin DrosophilaFemales—ImplicationsofEarlyX ChromosomeGeneExpression NatalieGladstein,MeghanN.McKeon,JamilaI.Horabin* DepartmentofBiomedicalSciences,FloridaStateUniversity,Tallahassee,Florida,UnitedStatesofAmerica Abstract Dosage compensation equates between the sexes the gene dose of sex chromosomes that carry substantially different genecontent.InDrosophila,thesinglemaleXchromosomeishypertranscribed byapproximatelytwo-foldtoeffectthis correction.Thekeygenesaremalelethalandappearnottoberequiredinfemales,oraffecttheirviability.Here,weshow thesemalelethalsdoinfacthavearoleinfemales,andtheyparticipateintheveryprocesswhichwilleventuallyshutdown their function—female determination. We find the male dosage compensation complex is required for upregulating transcriptionofthesexdeterminationmasterswitch,Sex-lethal,anX-linkedgenewhichisspecificallyactivatedinfemalesin responsetotheirtwoXchromosomes.ThelevelsofsomeX-linkedgenesarealsoaffected,andsomeofthesegenesare usedintheprocessofcountingthenumberofXchromosomesearlyindevelopment.Ourdatasuggestthatbeforethe femalestateisset,thegroundstateismaleandfemaleXchromosomeexpressioniselevated.Femalesthusutilizethemale dosagecompensationprocesstoamplifythesignalwhichdeterminestheirfate. Citation: Gladstein N, McKeon MN, Horabin JI (2010) Requirement of Male-Specific Dosage Compensation in Drosophila Females—Implications of Early X ChromosomeGeneExpression.PLoSGenet6(7):e1001041.doi:10.1371/journal.pgen.1001041 Editor:AsifaAkhtar,Max-Planck-InstituteofImmunobiology,Germany ReceivedMay6,2009;AcceptedJune24,2010;PublishedJuly29,2010 Copyright: ? 2010 Gladstein et al. This is an open-access article distributed under the terms of the Creative Commons Attribution License, which permits unrestricteduse,distribution,andreproductioninanymedium,providedtheoriginalauthorandsourcearecredited. Funding:Thisworkwassupportedinpartbystart-upfundsfromtheFloridaStateUniversityCollegeofMedicineandNIGMSGr