Resveratrol Acts Not through Anti-Aggregative Pathways but Mainly via Its Scavenging Properties against Aβ and Aβ-Metal Complexes Toxicity 英文参考文献.docVIP

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Resveratrol Acts Not through Anti-Aggregative Pathways but Mainly via Its Scavenging Properties against Aβ and Aβ-Metal Complexes Toxicity 英文参考文献.doc

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Resveratrol Acts Not through Anti-Aggregative Pathways but Mainly via Its Scavenging Properties against Aβ and Aβ-Metal Complexes Toxicity 英文参考文献

ResveratrolActsNotthroughAnti-AggregativePathways butMainlyviaItsScavengingPropertiesagainstAband Ab-MetalComplexesToxicity AlbertoGranzotto,PaoloZatta* CentroNazionaledelleRicerche,IstitutoTecnologieBiomediche(CNR-ITB),MetalloproteinsUnit,DepartmentofBiology,UniversityofPadova,Padova,Italy Abstract IthasbeenrecentlysuggestedthatresveratrolcanbeeffectiveinslowingdownAlzheimer’sdisease(AD)development.As reportedinmanybiochemicalstudies,resveratrolseemstoexertitsneuro-protectiverolethroughinhibitionofb-amyloid aggregation (Ab), by scavenging oxidants and exerting anti-inflammatory activities. In this paper, we demonstrate that resveratrol is cytoprotective in human neuroblastoma cells exposed to Ab and or to Ab-metal complex. Our findings suggestthatresveratrolactsnotthroughanti-aggregativepathwaysbutmainlyviaitsscavengingproperties. Citation:GranzottoA,ZattaP(2011)ResveratrolActsNotthroughAnti-AggregativePathwaysbutMainlyviaItsScavengingPropertiesagainstAbandAb-Metal ComplexesToxicity.PLoSONE6(6):e21565.doi:10.1371/journal.pone.0021565 Editor:PeterCsermely,SemmelweisUniversity,Hungary ReceivedApril1,2011;AcceptedJune2,2011;PublishedJune27,2011 Copyright: ?2011Granzotto,Zatta.Thisisanopen-accessarticledistributedunderthetermsoftheCreativeCommonsAttributionLicense,whichpermits unrestricteduse,distribution,andreproductioninanymedium,providedtheoriginalauthorandsourcearecredited. Funding:ThisworkwassupportedbyPRIN2007.Thefunderhadnoroleinstudydesign,datacollectionandanalysis,decisiontopublish,orpreparationofthe manuscript. CompetingInterests:Theauthorshavedeclaredthatnocompetinginterestsexist. *E-mail:zatta@bio.unipd.it Introduction the skin of red grapes and in wine; resveratrol antioxidant propertieshavebeenwelldemonstrated[20],withawiderangeof biological effects [21], and fortunately, the compound is free of adverse effects [22]. In addition, recent papers underline its Ab anti-aggregative properties [23–26]. Despite all these positive effects,amajorconstraintholdi