Role of iron in anaemic critically ill patients its time to investigate! 英文参考文献.docVIP

Critical Care October 2004 Vol 8 No 5 Piagnerelli and Vincent Commentary Role of iron in anaemic critically ill patients: it’s time to investigate! Michael Piagnerelli1 and Jean-Louis Vincent2 1Resident, Department of Intensive Care, Erasme Hospital, Free University of Brussels, Brussels, Belgium 2Head, Department of Intensive Care, Erasme Hospital, Free University of Brussels, Brussels, Belgium Corresponding author: Michael Piagnerelli, Michael.Piagnerelli@ulb.ac.be Published online: 3 June 2004 Critical Care 2004, 8:306-307 (DOI 10.1186/cc2884) This article is online at /content/8/5/306 ? 2004 BioMed Central Ltd See Review, page 356 Abstract Anaemia is a common problem in critically ill patients admitted to intensive care units. Many factors can be involved in its development, including rapid alterations in iron metabolism. Maintenance of iron homeostasis is a prerequisite for many essential biological processes and is a central element for the development of erythroid precursors and mature red blood cells. With the inflammatory process, iron distribution is disturbed, with decreased serum iron levels and increased iron stores. Little information is available on the precise role of alterations in iron metabolism in the development of iron anaemia in critically ill patients. Keywords anaemia, erythropoietin, iron, red blood cell Anaemia is a major cause of morbidity and mortality reticuloendothelial system [4,5]. Alteration in iron metabolism plays a central role in the development of anaemia [6]. The majority of the body’s iron content is incorporated into haemoglobin in developing erythroid precursors and mature RBCs, but this process is rapidly altered with the acute phase reaction. Typically, the inflammatory process is associated with low concentrations of serum iron, high ferritin (the protein responsible for iron storage), and low transferrin (the principal iron transporting glycoprotein) [7]. The underlying mechanisms are