血液病合并肺结核Ｔ淋巴细胞亚群的表达.docVIP

血液病合并肺结核Ｔ淋巴细胞亚群的表达 　　【摘要】 目的 了解血液病合并肺结核患者的免疫功能状态。方法 分析住院的29例血液病合并肺结核患者的外周血T淋巴细胞亚群的表达，并与同期住院的单纯肺结核40例和单纯血液病30例相比较。结果 血液病合并肺结核组与单纯血液病组、单纯肺结核组比较，CD3??+无显著性差异（P均＞0.05），而CD4??+、CD4??+/CD8??+显著降低，CD8??+显著增高（P＜0.05或0.01）。结论 血液病合并肺结核患者免疫功能低于单纯血液病和单纯肺结核患者。如何提高血液病合并肺结核患者机体细胞免疫功能，达到良好的疗效是临床医师值得注意的问题。 　　?ぁ竟丶?词】 血液病；肺结核；免疫功能；T淋巴细胞亚群?? 　　文章编号：1003-1383(2008)06-0649-02中图分类号：R 550.521 文献标识码：A?? 　　 　　ExpressionofTlymphocytesubsets inHematologicalDiseases??complicatedwithPulmonaryTuberculosis[HJ1*2]?? 　　LU Xiang,WANG Xiaochao,JIE Xuri?? 　　(Hematology Medical Department,The Affiliated Hospital of Youjiang ??Medical College for Nationalities，Baise Guangxi 533000)?お? 　　【Abstract】 Objective To investigate the state oftheimmunefunctionsinpatients with hematologicaldisease combined pulmonarytuberculosis. 　　Methods The expression ofTlymphocytesubsetsin 29 patients with hematologicaldisease combined pulmonarytuberculosishospitalizedfromMay2005toMay2007 were tested .The resultswerecomparedwith those of 40 cases with pulmonarytuberculosis and 30 cases with hematological disease hospitalized inthe sameperiod.Results Thepercentages of CD3??+inperipheralblood wasnostatisticalsignificance difference (P＞0.05)inthe hematologicaldiseasecomplicatedwithpulmonarytuberculosis, hematologicaldiseaseand pulmonarytuberculosis. But the percentages of CD4??+,theratioofCD4??+/CD8??+of the hematological diseasecomplicatedwithpulmonarytuberculosis patientsweremuchlowerthanthoseof hematologicaldiseases and pulmonarytuberculosis（P＜0.05）,the percentages ofCD8??+ inpatients with hematologicaldisease combined pulmonarytuberculosis was obviouslyhigher thanthoseinpatientsofhematologicaldiseaseand pulmonarytuberculosis（P＜0.05）. Con 　　clusion Theimmunefunctionsinpatients with hematologicaldisease combined pulmonarytuberculosiswaslowerthan thoseof hematologicaldiseaseand pulmonarytuberculosis. It high time for cinician to find a way toimproveimmunefunction and satisfactory curativeeffect ofpatients with hematolog