Role of testosterone in memory impairment of Alzheimer disease induced by Streptozotocin in male rats 英文参考文献.docVIP
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Role of testosterone in memory impairment of Alzheimer disease induced by Streptozotocin in male rats 英文参考文献
Seyedrezaetal.DARUJournalofPharmaceuticalSciences2012,20:98
/content/20/1/98
REVIEW ARTICLE
OpenAccess
Roleoftestosteroneinmemoryimpairmentof
AlzheimerdiseaseinducedbyStreptozotocinin
malerats
PourrabiSeyedreza1,MohajjelNayebiAlireza2*andHossiniSeyedebrahim1
Abstract
Backgroundandpurposeofthestudy:Recentstudiesdemonstratethatandrogens,beyondregulatingsexual
behavior,exertseveralneuroprotectivefunctionsinthebrain.Thepresentstudywasdesignedtoexploreeffectof
testosteroneinmemoryimpairmentinducedbyintra-cerebroventricular(icv)injectionofstreptozotocin(STZ)asa
modelofsporadicAD.
Methods:StudywascarriedoutonmaleWistarrats.Animalswererandomlydividedinto11equalgroups.
ExperimentalmodelofADwasinducedbybilateralicvinjectionofSTZatthedoseof750μg/Rat/10μlACSFat
days1and3.STZ-inducedmemoryimpairmentwasassessedtwoweeksafterthelastdoseofSTZbyusinga
passiveavoidancetask(1mA).Theintervalbetweentheplacementofanimalsintheilluminatedchamberandthe
entryintothedarkchamberwasmeasuredasastep-throughlatency(STL).Castrationwasperformedbysurgical
removingoftestisandbehavioralstudyofmemoryimpairmentwasdoneafter4weeks.
Results:ResultsofthisstudyshowedthaticvinjectionofSTZcouldinducemarked(p0.05)memoryimpairment
atthedoseof750μg/Rat/dissolve10μlCSF/bilateral/days1and3.Therefore,weusedthisdoseofSTZfor
inductionofexperimentalmodelofAD.Memorywasworsenedincastratedrats(P0.05)whencomparedwith
normalandsham-operatedanimals.Testosteronereplacementtherapy(1mg/kg,sc,for6days)in4weekcastrated
ratsrestoredmemoryuptothelevelofcontrolgroups.Testosteronehadnotanysignificanteffectonmemory
impairmentsofnon-castratedrats.
Majorconclusion:Accordingtotheobtainedresultsitcanbeconcludedthattestosteroneimprovescognitiveand
memoryimpairmentofAD.Wesuggestthattestosteronereplacementtherapymayhavebeneficialeffectin
amelioratingmemoryimpairmentsofsenilepatientssufferingfromAD.Furtherclinicalstudiesshouldbecarried
outtoprovepossibleusefuleffectoftestosteroneasanadjuvanttherapyinAD.
Keywords:Testosterone,Memory,Alzheimer
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