Screen Anti-influenza Lead Compounds That Target the PAC Subunit of H5N1 Viral RNA Polymerase 英文参考文献.docVIP

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Screen Anti-influenza Lead Compounds That Target the PAC Subunit of H5N1 Viral RNA Polymerase 英文参考文献.doc

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Screen Anti-influenza Lead Compounds That Target the PAC Subunit of H5N1 Viral RNA Polymerase 英文参考文献

ScreenAnti-influenzaLeadCompoundsThatTargetthe PAC SubunitofH5N1ViralRNAPolymerase LinLi1,3.,ShenghaiChang2,3.,JunfengXiang1,QianLi1,3,HuanhuanLiang2,YalinTang1*,YingfangLiu2* 1BeijingNationalLaboratoryforMolecularSciences(BNLMS),CenterforMolecularSciences,StateKeyLaboratoryforStructuralChemistryofUnstableandStableSpecies, InstituteofChemistry,ChineseAcademyofSciences,Beijing,China,2NationalLaboratoryofBiomacromolecules,InstituteofBiophysics,ChineseAcademyofSciences, Beijing,China,3GraduateUniversity,ChineseAcademyofSciences,Beijing,P.R.China Abstract The avian influenza (H5N1) viral RNA polymerase protein PAC was used as a target to screen nine chlorogenic acid derivatives for their polymerase inhibitor activity. Among them, seven compounds were PAC ligands, and four inhibited influenzaRNApolymeraseactivity.Theseresultsaidinthedesignofanti-influenzaagentsbasedoncaffeoylquinicacid. Citation: Li L, Chang S, Xiang J, Li Q, Liang H, et al. (2012) Screen Anti-influenza Lead Compounds That Target the PAC Subunit of H5N1 Viral RNA Polymerase.PLoSONE7(8):e35234.doi:10.1371/journal.pone.0035234 Editor:JunLiu,JohnsHopkinsSchoolofMedicine,UnitedStatesofAmerica ReceivedJune26,2011;AcceptedMarch13,2012;PublishedAugust24,2012 Copyright:?2012Lietal.Thisisanopen-accessarticledistributedunderthetermsoftheCreativeCommonsAttributionLicense,whichpermitsunrestricted use,distribution,andreproductioninanymedium,providedtheoriginalauthorandsourcearecredited. Funding:ThisworkwassupportedbytheNationalNaturalScienceFoundationofChinatoY.L.Tang,theNationalNaturalScienceFoundationof ChinaandtheMinistryofScienceandTechnology863Project(2006AA02A314)toY.F.Liu.Thefundershadnoroleinstudydesign,datacollection andanalysis,decisiontopublish,orpreparationofthemanuscript. CompetingInterests:Theauthorshavedeclaredthatnocompetinginterestsexist. *E-mail:tangyl@(YLT);liuy@(YFL) .Theseauthorscontributedequallytothiswork. Introduction PAC ligand and potential anti-influenza active compoun