Separating therapeutic efficacy from glucocorticoid side-effects in rodent arthritis using novel, liposomal delivery of dexamethasone phosphate long-term suppression of arthritis facilitates interval treatment 英文参考文献.docVIP

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Separating therapeutic efficacy from glucocorticoid side-effects in rodent arthritis using novel, liposomal delivery of dexamethasone phosphate long-term suppression of arthritis facilitates interval treatment 英文参考文献.doc

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Separating therapeutic efficacy from glucocorticoid side-effects in rodent arthritis using novel, liposomal delivery of dexamethasone phosphate long-term suppression of arthritis facilitates interval treatment 英文参考文献

Available online /content/11/6/R190 Research article Open Access Vol 11 No 6 Separating therapeutic efficacy from glucocorticoid side-effects in rodent arthritis using novel, liposomal delivery of dexamethasone phosphate: long-term suppression of arthritis facilitates interval treatment Una Rauchhaus1, Franz Werner Schwaiger2 and Steffen Panzner1 1Novosom AG, Weinbergweg 22, D-06120 Halle/Saale, Germany 2Aurigon Life Science GmbH, Bahnhofstrasse 9-15, D-82327 Tutzing, Germany Corresponding author: Steffen Panzner, steffen.panzner@ Received: 26 Mar 2009 Revisions requested: 21 Apr 2009 Revisions received: 24 Nov 2009 Accepted: 15 Dec 2009 Published: 15 Dec 2009 Arthritis Research Therapy 2009, 11:R190 (doi:10.1186/ar2889) This article is online at: /content/11/6/R190 ? 2009 Rauchhaus et al.; licensee BioMed Central Ltd. This is an open access article distributed under the terms of the Creative Commons Attribution License (/licenses/by/2.0), which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited. Abstract Introduction Glucocorticoids have extensively been used in the treatment of rheumatoid arthritis and other inflammatory diseases. However, their side-effects remain the major limitation in clinical use and an improved therapeutic index is needed. Results Liposomal DXM-P, but not free drug, resulted in a persistent anti-inflammatory effect. Comparable clinical benefit was achieved with a single administration of 4 mg/kg liposomal DXM-P or daily administrations of 1.6 mg/kg free drug for at least 7 days. For the liposomal form, but not for the free form, we observed a limitation of the suppression of the HPA axis in time and an absence of the drug-induced gluconeogenesis. Methods Therapeutic efficacy and persistence of free and liposomal dexamethasone phosphate (DXM-P) were determined in mouse collagen-induced arthritis. For regimens with equal therap