Sequence-based feature prediction and annotation of proteins 英文参考文献.docVIP

Review Sequence-based feature prediction and annotation of proteins Agnieszka S Juncker*, Lars J Jensen?, Andrea Pierleoni?, Andreas Bernsel§, Michael L Tress?, Peer Bork?, Gunnar von Heijne§, Alfonso Valencia?, Christos A Ouzounis￥, Rita Casadio? and S?ren Brunak* Addresses: *Center for Biological Sequence Analysis, Department of Systems Biology, Technical University of Denmark, DK-2800 Lyngby, Denmark. ?European Molecular Biology Laboratory, D-69117 Heidelberg, Germany. ?University of Bologna, Biocomputing Group, Via San Giacomo 9/2, 40126 Bologna, Italy. §Center for Biomembrane Research and Stockholm Bioinformatics Center, Department of Biochemistry and Biophysics, Stockholm University, SE-106 91 Stockholm, Sweden. ?Structural Biology and Biocomputing Programme, Spanish National Cancer Research Centre (CNIO), Melchor Fernández Almagro, 3, E-28029, Madrid, Spain. ￥KCL Centre for Bioinformatics, School of Physical Sciences and Engineering, King’s College London, London WC2R 2LS, UK. Correspondence: S?ren Brunak. Email: brunak@cbs.dtu.dk Published: 2 February 2009 Genome Biology 2009, 10:206 (doi:10.1186/gb-2009-10-2-206) The electronic version of this article is the complete one and can be found online at /2009/10/2/206 ? 2009 BioMed Central Ltd Abstract A recent trend in computational methods for annotation of protein function is that many prediction tools are combined in complex workflows and pipelines to facilitate the analysis of feature combinations, for example, the entire repertoire of kinase-binding motifs in the human proteome. As more sequenced genomes become available, computa- tional methods for predicting protein function from sequence data continue to be of high importance. In fact, such methods represent the only viable strategy for keeping up with the growth of genomic information. In the current era of pan- and metagenomics it is obvious that computational annotation is ess