Seroprevalence of Angiostrongylus cantonensis in Wild Rodents from the Canary Islands 英文参考文献.docVIP

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Seroprevalence of Angiostrongylus cantonensis in Wild Rodents from the Canary Islands 英文参考文献.doc

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Seroprevalence of Angiostrongylus cantonensis in Wild Rodents from the Canary Islands 英文参考文献

SeroprevalenceofAngiostrongyluscantonensisinWild RodentsfromtheCanaryIslands Aaro′nMartin-Alonso1,PilarForonda1*,Mar?′aAntonietaQuispe-Ricalde1,CarlosFeliu2 ,Basilio Valladares1 1UniversityInstituteofTropicalDiseasesandPublicHealthoftheCanaryIslands,UniversityofLaLaguna,LaLaguna,IslasCanarias,Espan?a,2DepartmentofMicrobiology andParasitology,UniversityofBarcelona,Barcelona,Catalun?a,Espan?a Abstract Background: Angiostrongylus cantonensis is a lungworm of rats (Muridae) that is the causative agent of human cerebral angiostrongyliasis. The life cycle of A. cantonensis involves rats and mollusks as the definitive and intermediate hosts, respectively.ThisstudywasdesignedtoincreasetheknowledgeabouttheoccurrenceanddistributionofA.cantonensisin itsdefinitivehostintheCanaryIslands,usingparasitologicalandserologicalanalysisindifferentareasandagegroups. Methodology/PrincipalFindings:Between2009and2010,54blackrats(Rattusrattus)fromTenerifewerecapturedfrom six human-inhabited areas and sera samples were obtained. The lung nematodes were identified by morphological and molecular tools as A. cantonensis. The 31-kDa glycoprotein antigen was purified from A. cantonensis adult worms by electrophoresis and electroelution. Of the 54 tested rodents, 30 showed IgG antibodies against A. cantonensis 31-kDa antigenbyELISA.Therefore,theoverallseroprevalencewas55.6%(95%CI:42.4–68).Seroprevalentrodentswerefoundin allthe6areas.This31-kDaantigenwasnotrecognizedbysomeseraofratsinfectedbyotherhelminthspecies(butnotA. cantonensis).SeroprevalenceofIgGantibodiesagainstA.cantonensisandprevalencebasedonthepresenceofadultworms showedsignificantcorrelation(R2=0.954,p,0.05). Conclusions/Significance:ThepresentresultscouldindicateahighprevalenceofA.cantonensisinTenerifeandsuggestthe inclusionoftwonewzonesinthedistributionareaoftheparasite.ThecommonnessandwidedistributionofA.cantonensis inratsimpliesthepresenceofintermediatehosts,indicatingthathumansmaybeatriskofgettinginfected. Citation:Martin-AlonsoA