Serum Activity of Platelet-Activating Factor Acetylhydrolase Is a Potential Clinical Marker for Leptospirosis Pulmonary Hemorrhage 英文参考文献.docVIP

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Serum Activity of Platelet-Activating Factor Acetylhydrolase Is a Potential Clinical Marker for Leptospirosis Pulmonary Hemorrhage 英文参考文献.doc

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Serum Activity of Platelet-Activating Factor Acetylhydrolase Is a Potential Clinical Marker for Leptospirosis Pulmonary Hemorrhage 英文参考文献

SerumActivityofPlatelet-ActivatingFactor AcetylhydrolaseIsaPotentialClinicalMarkerfor LeptospirosisPulmonaryHemorrhage JunweiYang1.,YixuanZhang2.,JingXu3,4,YanGeng2,XiaoyingChen2,HongliangYang3¤ ,Shengnian Wang5,HenganWang3,XuchengJiang3,XiaokuiGuo3,GuopingZhao1,5,6,7* 1LaboratoryofSyntheticBiology,InstituteofPlantPhysiologyandEcology,ShanghaiInstitutesforBiologicalSciences,ChineseAcademyofSciences,Shanghai,China, 2School of Life Science and Biopharmaceutical, Shenyang Pharmaceutical University, Shenyang, China, 3Department of Medical Microbiology and Parasitology, DepartmentofPathologyandDepartmentofAnimalBiotechnology,ShanghaiJiaoTongUniversity,Shanghai,China,4ShanghaiInstituteofHealthSciences,Shanghai, China, 5National Engineering Center for Biochip at Shanghai, Shanghai, China, 6Shanghai-MOST Key Laboratory for Health and Disease Genomics, Chinese National HumanGenomeCenteratShanghai,Shanghai,China,7DepartmentofMicrobiologyandLiKaShingInstituteofHealthSciences,TheChineseUniversityofHongKong, PrinceofWalesHospital,Shatin,NewTerritories,HongKongSAR,China Abstract Pulmonary hemorrhage has been recognized as a major, often lethal, manifestation of severe leptospirosis albeit the pathogenesis remains unclear. The Leptospira interrogans virulent serogroup Icterohaemorrhagiae serovar Lai encodes a protein(LA2144),whichexhibitedtheplatelet-activatingfactoracetylhydrolase(PAF-AH)activityinvitrosimilartothatof humanserumwithrespecttoitssubstrateaffinityandspecificityandthusdesignatedL-PAF-AH.Ontheotherhand,the primaryaminoacidsequenceofL-PAF-AHishomologoustothea1-subunitofthebovinebrainPAF-AHisoformI.TheL- PAF-AH was proven to be an intracellular protein, which was encoded unanimously and expressed similarly in either pathogenicorsaprophyticleptospires.MongoliangerbilisanappropriateexperimentalmodeltostudythePAF-AHlevelin serum with its basal activity level comparable to that of human while elevated directly associated with the course of pulmonaryhemorrhageduringseverel