Sesquiterpenes from Cymbopogon proximus 英文参考文献.docVIP

Molecules 2003, 8, 670-677 molecules ISSN 1420-3049 / Sesquiterpenes from Cymbopogon proximus Hesham I. El-Askary*, Meselhy R. Meselhy and Ahmed M. Galal Pharmacognosy Department, Faculty of Pharmacy, Cairo University, 11562, Cairo, Egypt; Fax: (+20) 2-3635140. * Author to whom correspondence should be addressed; e-mail heshamaskary@ Received: 20 March 2003; in revised form: 23 July 2003 / Accepted: 26 July 2003 / Published: 15 August 2003 Abstract: In addition to four previously reported compounds: proximadiol (1), 5α-hydroxy-β-eudesmol (2), 1β-hydroxy-β-eudesmol (4) and 1β-hydroxy-α-eudesmol (5), two new sesquiterpenes, 5α-hydroperoxy-β-eudesmol (3) and 7α,11-dihydroxy- cadin-10(14)-ene (6) were isolated from the unsaponifiable fraction of the petroleum ether extract of Cymbopogon proximus STAPF. Isolation of compounds 2, 4 and 5 from the genus Cymbopogon is reported for the first time. The structure elucidation of these compounds was based primarily on 1D and 2D-NMR analyses. Keywords: Cymbopogon proximus; Gramineae; proximadiol; sesquiterpenes; NMR; MS. Introduction Cymbopogon proximus STAPF. (Gramineae) is a weed known as Halfabar that grows in the Egyptian desert. It is highly reputed in Egyptian folk medicine as an effective renal antispasmodic and diuretic agent [1,2]. Preliminary work on Cymbopogon proximus indicated that the unsaponifiable fraction of the petroleum ether extract of this plant possesses potent and unique antispasmodic properties, as it produces relaxation of the smooth muscle fibers without abolishing the propulsive movement of the tissue [3-6]. Bioactivity-assisted fractionation of the hexane extract lead to isolation of an active principle, proximadiol (0.02% yield) [5,6] and its bicyclic sesquiterpene diol chemical structure was confirmed by the spectral data [7-9]. In addition, two sesquiterpenes, elemol