Serum MicroRNA-21 as Marker for Necroinflammation in Hepatitis C Patients with and without Hepatocellular Carcinoma 英文参考文献.docVIP
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Serum MicroRNA-21 as Marker for Necroinflammation in Hepatitis C Patients with and without Hepatocellular Carcinoma 英文参考文献
SerumMicroRNA-21asMarkerforNecroinflammationin
HepatitisCPatientswithandwithoutHepatocellular
Carcinoma
VerenaBihrer1.,OliverWaidmann1.,MireenFriedrich-Rust1,NicoleForestier1,SimoneSusser1,Jo¨rg
Haupenthal1¤,MartinWelker1,YingShi1,JanPeveling-Oberhag1,AndreasPolta1,MichaelvonWagner1,
HeinfriedH.Radeke2,ChristophSarrazin1,Jo¨rgTrojan1,StefanZeuzem1,BerndKronenberger1,
AlbrechtPiiper1*
1DepartmentofMedicineI,UniversityofFrankfurt/M.,Frankfurt,Germany,2InstituteofPharmacology/ZAFES,UniversityofFrankfurt/M.,Frankfurt,Germany
Abstract
Background: MicroRNA-21 (miR-21) is up-regulated in tumor tissue of patients with malignant diseases, including
hepatocellularcarcinoma(HCC).ElevatedconcentrationsofmiR-21havealsobeenfoundinseraorplasmafrompatients
with malignancies, rendering it an interesting candidate as serum/plasma marker for malignancies. Here we correlated
serummiR-21levelswithclinicalparametersinpatientswithdifferentstagesofchronichepatitisCvirusinfection(CHC)and
CHC-associatedHCC.
Methodology/Principal Findings: 62 CHC patients, 29 patients with CHC and HCC and 19 healthy controls were
prospectivelyenrolled.RNAwasextractedfromtheseraandmiR-21aswellasmiR-16levelswereanalyzedbyquantitative
real-timePCR;miR-21levels(normalizedbymiR-16)werecorrelatedwithstandardliverparameters,histologicalgradingand
staging of CHC. The data show that serum levels of miR-21 were elevated in patients with CHC compared to healthy
controls(P,0.001);therewasnodifferencebetweenserummiR-21inpatientswithCHCandCHC-associatedHCC.Serum
miR-21levelscorrelatedwithhistologicalactivityindex(HAI)intheliver(r=20.494,P=0.00002),alanineaminotransferase
(ALT) (r=20.309, P=0.007), aspartate aminotransferase (r=20.495, P=0.000007), bilirubin (r=20.362, P =0.002),
internationalnormalizedratio(r=20.338,P=0.034)andc-glutamyltransferase(r=20.244,P=0.034).Multivariateanalysis
revealed that ALT and miR-21 serum levels were independently associated with HAI. At a cut-off dCT of 1.96, miR-21
discriminated bet
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