Serum cathepsin K levels of patients with longstanding rheumatoid arthritis correlation with radiological destruction 英文参考文献.docVIP

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Serum cathepsin K levels of patients with longstanding rheumatoid arthritis correlation with radiological destruction 英文参考文献.doc

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Serum cathepsin K levels of patients with longstanding rheumatoid arthritis correlation with radiological destruction 英文参考文献

Available online /content/7/1/R65 Research article Open Access Vol 7 No 1 Serum cathepsin K levels of patients with longstanding rheumatoid arthritis: correlation with radiological destruction Martin Skoumal1,2, Günther Haberhauer1, Gernot Kolarz1, Gerhard Hawa3, Wolfgang Woloszczuk4 and Anton Klingler5 1Institut für Rheumatologie der Kurstadt Baden in Kooperation mit der Donauuniversit?t Krems, Austria 2Rheumasonderkrankenanstalt der SVA der gewerblichen Wirtschaft, Baden, Austria 3Biomedica Medizinprodukte GmbH CO KG, Vienna, Austria 4L Boltzmann Institut für experimentelle Endokrinologie, Vienna, Austria 5Theoretical Surgery Unit, Department of General and Transplant Surgery, University Hospital, Innsbruck, Austria Corresponding author: Martin Skoumal, martin.skoumal@ Received: 16 Aug 2004 Revisions requested: 22 Sep 2004 Revisions received: 3 Oct 2004 Accepted: 11 Oct 2004 Published: 10 Nov 2004 Arthritis Res Ther 2005, 7:R65-R70 (DOI 10.1186/ar1461) ? 2004 Skoumal et al., licensee BioMed Central Ltd. /content/7/1/R65 This is an Open Access article distributed under the terms of the Creative Commons Attribution License (/licenses/by/ 2.0), which permits unrestricted use, distribution and reproduction in any medium, provided the original work is cited. Abstract Cathepsin K is a cysteine protease that plays an essential role in found increased levels of cathepsin K compared with a healthy control group and found a significant correlation with osteoclast function and in the degradation of protein components of the bone matrix by cleaving proteins such as collagen type I, collagen type II and osteonectin. Cathepsin K therefore plays a role in bone remodelling and resorption in diseases such as osteoporosis, osteolytic bone metastasis and rheumatoid arthritis. We examined cathepsin K in the serum of 100 patients with active longstanding rheumatoid arthritis. We radiological destruction, measured by the Larsen sc