Seroprevalence of Fecal-Oral Transmitted Hepatitis A and E Virus Antibodies in Burkina Faso 英文参考文献.docVIP
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Seroprevalence of Fecal-Oral Transmitted Hepatitis A and E Virus Antibodies in Burkina Faso 英文参考文献
SeroprevalenceofFecal-OralTransmittedHepatitisA
andEVirusAntibodiesinBurkinaFaso
KuanAbdoulayeTraore′1,HortenseRouamba2,YacoubaNe′bie′3,MahamadouSanou3,AlfredS.Traore′1,
NicolasBarro1*.,PierreRoques
4,5 .
*
1Centre de Recherche en Sciences Biologique Alimentaire Nutritionnelles (CRSBAN), Universite′ de Ouagadougou, Ouagadougou, Burkina Faso, 2Centre National de
TransfusionSanguine,Ouagadougou,BurkinaFaso,3Centreme′dical deSamandin,Ouagadougou,BurkinaFaso,4DivisionofImmuno-Virologie,InstituteofEmerging
DiseasesandInnovativeTherapies,Commissariata` l’EnergieAtomique(CEA),Fontenay-aux-Roses,France,5UniteMixtedeRechercheE1,UniversityParisSud11,Orsay,
France
Abstract
HepatitisAvirus(HAV)andhepatitisEvirus(HEV)infectionsoccurchieflyasaresultofunhygienicconditions.Thepurpose
of this study was to assess the seroprevalence of antibodies to both viruses in central Burkina Faso in the absence of
arecordedhepatitisepidemic.Serumsamplesfrom178blooddonors(131malesand47females)andfrom189pregnant
women were collected from November 2010 to March 2012, at blood banks and medical centers in Burkina Faso. An
immunochromatography test was used to screen for Anti-HAV IgM and IgG in a subgroup of 91 blood donors and 100
pregnant women. The seroprevalence of anti-HAV IgG was 14.3% [CI95, 7.1–21.4%] for all blood donors and 23% [CI95,
14.8–31.2%]forpregnantwomen.Anti-HEVIgGweredetectedusingtheELISAkitsDandWantaiandwerefoundin
19.1%[CI95,13.3–24.9%]oftheblooddonorsand11.6%[CI95,7.1–16.2%]ofthepregnantwomen.Theseroprevalencesof
anti-HAVandanti-HEVIgGsdidnotdiffersignificantlybetweenmenandwomenblooddonors.Anti-HAVIgMwasdetected
in3.3%oftheblooddonorsandin2%ofthepregnantwomen.Thesefindingsforasymptomaticindividualsindicatethat
theHAVandHEVcirculateatlowbutsignificantlevels. Thisisthefirstevaluationoftheacutehepatitisvirus burdenin
BurkinaFasoandtheunderlyingepidemiologicstatusofthepopulation.
Citation:Traore′KA,RouambaH,Ne′bie′Y,SanouM,Traore′AS,etal.(2012)SeroprevalenceofFeca
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