Sequence-Specific Targeting of Dosage Compensation in Drosophila Favors an Active Chromatin Context 英文参考文献.docVIP

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Sequence-Specific Targeting of Dosage Compensation in Drosophila Favors an Active Chromatin Context 英文参考文献.doc

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Sequence-Specific Targeting of Dosage Compensation in Drosophila Favors an Active Chromatin Context 英文参考文献

Sequence-SpecificTargetingofDosageCompensationin DrosophilaFavorsanActiveChromatinContext ArtyomA.Alekseyenko1,2.,JoshuaW.K.Ho1,3.,ShouyongPeng1,3.,MarnieGelbart1,2 , MichaelY.Tolstorukov1,3,AnnettePlachetka1,2,PeterV.Kharchenko1,3,YoungsookL.Jung1,3 AndreyA.Gorchakov1,2,EricaLarschan4,TingtingGu5,AkiMinoda6,7,NicoleC.Riddle5, YuriB.Schwartz8,SarahC.R.Elgin5,GaryH.Karpen6,VincenzoPirrotta9,MitziI.Kuroda1,2*, , PeterJ.Park1,3 * 1DivisionofGenetics,DepartmentofMedicine,BrighamandWomen’sHospital,HarvardMedicalSchool,Boston,Massachusetts,UnitedStatesofAmerica,2Department of Genetics, Harvard Medical School, Boston, Massachusetts, United States of America, 3Center for Biomedical Informatics, Harvard Medical School, Boston, Massachusetts,UnitedStatesofAmerica,4DepartmentofMolecularBiology,CellBiology,andBiochemistry,BrownUniversity,Providence,RhodeIsland,UnitedStatesof America,5DepartmentofBiology,WashingtonUniversityinSt.Louis,St.Louis,Missouri,UnitedStatesofAmerica,6DepartmentofMolecularandCellBiology,University ofCalifornia Berkeley,Berkeley,California,UnitedStatesofAmerica, 7Department ofGenomeDynamics, LawrenceBerkeley NationalLab,Berkeley,California,United States of America, 8Department of Molecular Biology, Umea? University, Umea?, Sweden, 9Department of Molecular Biology and Biochemistry, Rutgers University, Piscataway,NewJersey,UnitedStatesofAmerica Abstract TheDrosophila MSLcomplexmediatesdosagecompensation byincreasingtranscription ofthesingleXchromosomein malesapproximatelytwo-fold.ThisisaccomplishedthroughrecognitionoftheXchromosomeandsubsequentacetylation ofhistoneH4K16onX-linkedgenes.InitialbindingtotheXisthoughttooccurat‘‘entrysites’’thatcontainaconsensus sequencemotif(‘‘MSLrecognitionelement’’orMRE).However,thismotifisonly,2foldenrichedonX,andonlyafraction ofthemotifsonXareinitiallytargeted.Hereweaskwhetherchromatincontextcoulddistinguishbetweenutilizedand non-utilized copies of the motif, by comparing their relative enrichment for histone modifi