Seroprevalence of parvovirus B19 IgG in children affected by juvenile idiopathic arthritis 英文参考文献.docVIP

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Seroprevalence of parvovirus B19 IgG in children affected by juvenile idiopathic arthritis 英文参考文献.doc

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Seroprevalence of parvovirus B19 IgG in children affected by juvenile idiopathic arthritis 英文参考文献

Available online /content/9/4/R82 Research article Open Access Vol 9 No 4 Seroprevalence of parvovirus B19 IgG in children affected by juvenile idiopathic arthritis Benedikt Weissbrich1, Yvonne Sü?-Fr?hlich1,2 and Hermann J Girschick2 1Institute of Virology and Immunobiology, University of Würzburg, Versbacher Str 7, 97078 Würzburg, Germany 2Section of Paediatric Rheumatology, Immunology and Infectious diseases, Childrens Hospital, University of Würzburg, Josef-Schneider-Str 2, 97080 Würzburg, Germany Corresponding author: Benedikt Weissbrich, weissbrich@vim.uni-wuerzburg.de Received: 25 May 2007 Revisions requested: 19 Jul 2007 Revisions received: 29 Jul 2007 Accepted: 30 Aug 2007 Published: 30 Aug 2007 Arthritis Research Therapy 2007, 9:R82 (doi:10.1186/ar2281) This article is online at: /content/9/4/R82 ? 2007 Weissbrich et al.; licensee BioMed Central Ltd. This is an open access article distributed under the terms of the Creative Commons Attribution License (/licenses/by/2.0), which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited. Abstract Parvovirus (PV) B19 is the causative agent of the childhood disease erythema infectiosum. An association of PV B19 with association between PV B19 and JIA, then the prevalence of PV B19 IgG in the children with JIA should be higher than in the control group. PV B19 IgG status was tested in 406 children with JIA and related diseases, and in 146 children constituting a control group. The percentage of PV B19 IgG positive children was not significantly elevated in the disease subgroups compared with age-matched control groups. In conclusion, our findings do not support the hypothesis that human parvovirus B19 is involved in the pathogenesis of JIA. chronic arthropathies, sometimes resembling rheumatoid arthritis or juvenile idiopathic arthritis (JIA), has repeatedly been described. Other studies, however, have