Seroprevalence of Pandemic H1N1 Antibody among Health Care Workers in Hong Kong Following Receipt of Monovalent 2009 H1N1 Influenza Vaccine 英文参考文献.docVIP

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Seroprevalence of Pandemic H1N1 Antibody among Health Care Workers in Hong Kong Following Receipt of Monovalent 2009 H1N1 Influenza Vaccine 英文参考文献.doc

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Seroprevalence of Pandemic H1N1 Antibody among Health Care Workers in Hong Kong Following Receipt of Monovalent 2009 H1N1 Influenza Vaccine 英文参考文献

SeroprevalenceofPandemicH1N1Antibodyamong HealthCareWorkersinHongKongFollowingReceiptof Monovalent2009H1N1InfluenzaVaccine YingZhou1,DianeM.W.Ng1,Wing-HongSeto2,DennisK.M.Ip1,HenryK.H.Kwok2,EdwardS.K.Ma3, SophiaNg1,LincolnL.H.Lau1,J.S.MalikPeiris3,4,BenjaminJ.Cowling1* 1InfectiousDiseaseEpidemiologyGroup,SchoolofPublicHealth,TheUniversityofHongKong,HongKongSpecialAdministrativeRegion,China,2HospitalAuthority, HongKongSpecialAdministrativeRegion,China,3DepartmentofMicrobiology,TheUniversityofHongKong,HongKongSpecialAdministrativeRegion,China,4HKU- PasteurResearchCentre,HongKongSpecialAdministrativeRegion,China Abstract Background:Healthcareworkersinmanycountriesarerecommendedtoreceiveinfluenzavaccinetoprotectthemselvesas wellaspatients.AmonovalentH1N1vaccinebecameavailableinHongKonginDecember2009andaround10%oflocal healthcareworkershadreceivedthevaccinebyFebruary2010. Methods:Weconductedacross-sectionalstudyoftheprevalenceofantibodytopandemic(H1N1)2009amongHCWsin HongKonginFebruary–March2010followingthefirstpandemicwaveandthepH1N1vaccinationcampaign.Inthisstudy we focus on the subset of healthcare workers who reported receipt of non-adjuvanted monovalent 2009 H1N1 vaccine (Panenza,SanofiPasteur).SeracollectedfromHCWsweretestedforantibodyagainstthepH1N1virusbyhemagglutination inhibition(HI)andviralneutralization(VN)assays. Results:Weenrolled703HCWs.Among104HCWswhoreportedreceiptofpH1N1vaccine,54%(95%confidenceinterval (CI):44%–63%)hadantibodytiter$1:40byHIand42%(95%CI:33%–52%)hadantibodytiter$1:40byVN.Theproportion ofHCWswithantibodytiter$1:40byHIandVNsignificantlydecreasedwithage,andtheproportionwithantibodytiter $1:40 by VN was marginally significantly lower among HCWs who reported prior receipt of 2007–08 seasonal influenza vaccine(oddsratio:0.43;95%CI:0.19–1.00).Afteradjustmentforage,theeffectofpriorseasonalvaccinereceiptwasnot statisticallysignificant. Conclusions:OurfindingssuggestthatmonovalentH1N1vaccinemayhavehadsuboptimalimmunogenicityinHCWsin HongKong.Lar