Seroprevalence of Pandemic (H1N1) 2009 in Pregnant Women in China An Observational Study 英文参考文献.docVIP
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Seroprevalence of Pandemic (H1N1) 2009 in Pregnant Women in China An Observational Study 英文参考文献
SeroprevalenceofPandemic(H1N1)2009inPregnant
WomeninChina:AnObservationalStudy
XiangHuo1.,XianQi1.,FenyangTang1.,RongqiangZu1,LiangLi1,BinWu1,YuanfangQin1,HongJi1,
JianguangFu1,ShenjiaoWang1,HuaTian1,ZhibinHu2,HaitaoYang1,MinghaoZhou1,HuaWang1,
FengcaiZhu1*
1JiangsuProvincialCenterforDiseasePreventionandControl,Nanjing,China,2CollegeofPublicHealth,NanjingMedicalUniversity,Nanjing,China
Abstract
Background: We investigated the seropositive rates and persistence of antibody against pandemic (H1N1) 2009 virus
(pH1N1)inpregnantwomenandvoluntaryblooddonorsafterthesecondwaveofthepandemicinNanjing,China.
Methodology/PrincipalFindings:Serumsamplesofunvaccinatedpregnantwomen(n=720)andvoluntaryblooddonors
(n=320)werecollectedafterthesecondwaveof2009pandemicinNanjing.AllsamplesweretestedagainstpH1N1strain
(A/California/7/2009)withhemagglutinationinhibitionassay.Asignificantdeclineinseropositiverates,fromabove50%to
about 20%, was observed in pregnant women and voluntary blood donors fifteen weeks after the second wave of the
pandemic.AquarterofthesamplesweretestedagainstaseasonalH1N1strain(A/Brisbane/59/2007).Theantibodytiters
against pH1N1 strain were found to correlate positively with those against seasonal H1N1 strain. The correlation was
modestbutstatisticallysignificant.
ConclusionsandSignificance:Thehighseropositiveratesinbothpregnantwomenandvoluntaryblooddonorssuggested
thatthepH1N1virushadwidelyspreadinthesetwopopulations.Immunityderivedfromnaturalinfectionseemednotto
bepersistentwell.
Citation: HuoX,QiX,TangF,ZuR, LiL,etal.(2011) SeroprevalenceofPandemic (H1N1) 2009inPregnant Womenin China:An ObservationalStudy. PLoS
ONE6(3):e17995.doi:10.1371/journal.pone.0017995
Editor:VernonLee,NationalUniversityofSingapore,Singapore
ReceivedSeptember28,2010;AcceptedFebruary20,2011;PublishedMarch18,2011
Copyright:?2011Huoetal.Thisisanopen-accessarticledistributedunderthetermsoftheCreativeCommonsAttributionLicense,whichpermitsunrestricted
use,distribution,andreproductioninan
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