Serum Cholesterol and Nigrostriatal R2 Values in Parkinsons Disease 英文参考文献.docVIP

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Serum Cholesterol and Nigrostriatal R2 Values in Parkinsons Disease 英文参考文献.doc

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Serum Cholesterol and Nigrostriatal R2 Values in Parkinsons Disease 英文参考文献

SerumCholesterolandNigrostriatalR2*Valuesin Parkinson’sDisease GuangweiDu1,MechelleM.Lewis1,2,MicheleL.Shaffer6,HongleiChen7,QingX.Yang3,4, RichardB.Mailman1,2,XuemeiHuang1,2,3,4,5 * 1Department of Neurology, Pennsylvania State University-Milton S. Hershey Medical Center, Hershey, Pennsylvania, United States of America, 2Department of Pharmacology,PennsylvaniaStateUniversity-MiltonS.HersheyMedicalCenter,Hershey,Pennsylvania,UnitedStatesofAmerica,3DepartmentofRadiology,Pennsylvania StateUniversity-MiltonS.HersheyMedicalCenter,Hershey,Pennsylvania,UnitedStatesofAmerica,4DepartmentofNeurosurgery,PennsylvaniaStateUniversity-MiltonS. HersheyMedicalCenter,Hershey,Pennsylvania,UnitedStatesofAmerica,5DepartmentofKinesiology,PennsylvaniaStateUniversity-MiltonS.HersheyMedicalCenter, Hershey, Pennsylvania, United States of America, 6Department of Public Health Sciences, Pennsylvania State University-Milton S. Hershey Medical Center, Hershey, Pennsylvania,UnitedStatesofAmerica,7EpidemiologyBranch,NationalInstituteofEnvironmentalHealthSciences,ResearchTrianglePark,NorthCarolina,UnitedStates ofAmerica Abstract Background:TheoccurrenceofParkinson’sdisease(PD)isknowntobeassociatedbothwithincreasednigrostriataliron contentandwithlowserumcholesterolandPD,buttherehasbeennostudytodetermineapotentialrelationshipbetween thesetwofactors. Methods: High-resolution MRI (T1-, T2, and multiple echo T2*-weighted imaging) and fasting lipid levels were obtained from40patientswithPDand29healthycontrols.IroncontentwasestimatedfrommeanR2*values(R2*=1/T2*)calculated foreachnigrostriatalstructureincludingsubstantianigra,caudate,putamen,andglobuspallidus.Thiswascorrelatedwith serumcholesterollevelsaftercontrollingforage,gender,andstatinuse. Results:InpatientswithPD,higherserumcholesterollevelswereassociatedwithlowerironcontentinthesubstantianigra (R=20.43,p=0.011fortotal-cholesterol,R=20.31,p=0.080forlow-densitylipoprotein)andglobuspallidus(R=20.38, p=0.028 for total-cholesterol, R=20.27, p=0.127 fo