Serological Response to the 2009 Pandemic Influenza A (H1N1) Virus for Disease Diagnosis and Estimating the Infection Rate in Thai Population 英文参考文献.docVIP
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Serological Response to the 2009 Pandemic Influenza A (H1N1) Virus for Disease Diagnosis and Estimating the Infection Rate in Thai Population 英文参考文献
SerologicalResponsetothe2009PandemicInfluenzaA
(H1N1)VirusforDiseaseDiagnosisandEstimatingthe
InfectionRateinThaiPopulation
HatairatLerdsamran1,ChakraratPittayawonganon2,PhisanuPooruk1,AnekMungaomklang3 ,Sopon
Iamsirithaworn2,PrasertThongcharoen1,UraiwanKositanont1,PrasertAuewarakul1 ,Kulkanya
Chokephaibulkit4,SineenatOota5,WarinPongkankham6,PatummalSilaporn2,SupaloekKomolsiri1,
PiromNoisumdaeng1,TaweeChotpitayasunondh7,ChariyaSangsajja8,WitthawatWiriyarat9 ,Suda
Louisirirotchanakul1,PilaipanPuthavathana1*
1Department of Microbiology, Faculty of Medicine Siriraj Hospital, Mahidol University, Bangkok,Thailand, 2Bureau of Epidemiology, Department of Disease Control,
MinistryofPublicHealth,Nonthaburi,Thailand,3MaharatNakhonratchasimaHospital,MinistryofPublicHealth,Nakhonratchasima,Thailand,4DepartmentofPediatrics,
Faculty of Medicine Siriraj Hospital, Mahidol University, Bangkok, Thailand, 5The National Blood Center, The Thai Red Cross Society, Bangkok, Thailand, 6Division of
PreventiveMedicine,NavalMedicalDepartment,RoyalThaiNavy,ChonBuri,Thailand,7QueenSirikitNationalInstituteofChildHealth,MinistryofPublicHealth,Bangkok,
Thailand, 8Bamrasnaradura Infectious Disease Institute, Ministry of Public Health, Nonthaburi, Thailand, 9Faculty of Veterinary Science, Mahidol University, Nakhon
Pathom,Thailand
Abstract
Background: Individuals infected with the 2009 pandemic virus A(H1N1) developed serological response which can be
measuredbyhemagglutination-inhibition(HI)andmicroneutralization(microNT)assays.
Methodology/PrincipalFindings:MicroNTandHIassaysforspecificantibodytothe2009pandemicviruswereconducted
inserumsamplescollectedattheendofthefirstepidemicwavefromvariousgroupsofThaipeople:laboratoryconfirmed
cases,blooddonorsandhealthcareworkers(HCW)inBangkokandneighboringprovince,generalpopulationintheNorth
andtheSouth,aswellasarchivalseracollectedatpre-andpost-vaccinationfromvaccineeswhoreceivedinfluenzavaccine
ofthe2006season.Thisstudydemonstratedthatgooseerythrocytesyiel
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