Sequence context affects the rate of short insertions and deletions in flies and primates 英文参考文献.docVIP

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Sequence context affects the rate of short insertions and deletions in flies and primates 英文参考文献.doc

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Open Access Research 2008TanayVolumeand9, ISiggiassue 2, Article R37 Sequence context affects the rate of short insertions and deletions in flies and primates Amos Tanay*? and Eric D Siggia* Addresses: *Center for Studies in Physics and Biology, The Rockefeller University, York Ave, New York, NY 10021, USA. ?Department of Computer Science and Applied Mathematics, Weizmann Institute of Science, Rehovot, Israel 76100. Correspondence: Amos Tanay. Email: amos.tanay@weizmann.ac.il Published: 21 February 2008 Received: 14 June 2007 Revised: 25 September 2007 Accepted: 21 February 2008 Genome Biology 2008, 9:R37 (doi:10.1186/gb-2008-9-2-r37) The electronic version of this article is the complete one and can be found online at /2008/9/2/R37 ? 2008 Tanay and Siggia; licensee BioMed Central Ltd. This is an open access article distributed under the terms of the Creative Commons Attribution License (/licenses/by/2.0), which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited. SequencecipficAlennaglythscontextisscoafnavlaofrygindelsebcoy mlectionore thaofn short100 foinsertionsld, dependanding deletionson the surinroprimatesunding seandquenfliesce. shows/p that the rate of insertions or deletions of spe- Abstract Background: Insertions and deletions (indels) are an important evolutionary force, making the evolutionary process more efficient and flexible by copying and removing genomic fragments of various lengths instead of rediscovering them by point mutations. As a mutational process, indels are known to be more active in specific sequences (like micro-satellites) but not much is known about the more general and mechanistic effect of sequence context on the insertion and deletion susceptibility of genomic loci. Results: Here we analyze a large collection of high confidence short insertions and deletions in primates and flies, revealing extensive correlations betw