Serum BDNF Concentrations Show Strong Seasonal Variation and Correlations with the Amount of Ambient Sunlight 英文参考文献.docVIP

下载本文档

4
0
约4.16万字
约 7页
2017-05-13 发布于上海
举报
版权申诉

Serum BDNF Concentrations Show Strong Seasonal Variation and Correlations with the Amount of Ambient Sunlight 英文参考文献.doc

1、本文档共7页，可阅读全部内容。
2、原创力文档（book118）网站文档一经付费（服务费），不意味着购买了该文档的版权，仅供个人/单位学习、研究之用，不得用于商业用途，未经授权，严禁复制、发行、汇编、翻译或者网络传播等，侵权必究。
3、本站所有内容均由合作方或网友上传，本站不对文档的完整性、权威性及其观点立场正确性做任何保证或承诺！文档内容仅供研究参考，付费前请自行鉴别。如您付费，意味着您自己接受本站规则且自行承担风险，本站不退款、不进行额外附加服务；查看《如何避免下载的几个坑》。如果您已付费下载过本站文档，您可以点击这里二次下载。
4、如文档侵犯商业秘密、侵犯著作权、侵犯人身权等，请点击“版权申诉”（推荐），也可以打举报电话：400-050-0827(电话支持时间：9:00-18:30)。
5、该文档为VIP文档，如果想要下载，成为VIP会员后，下载免费。
6、成为VIP后，下载本文档将扣除1次下载权益。下载后，不支持退款、换文档。如有疑问请联系我们。
7、成为VIP后，您将拥有八大权益，权益包括：VIP文档下载权益、阅读免打扰、文档格式转换、高级专利检索、专属身份标志、高级客服、多端互通、版权登记。
8、VIP文档为合作方或网友上传，每下载1次，网站将根据用户上传文档的质量评分、类型等，对文档贡献者给予高额补贴、流量扶持。如果你也想贡献VIP文档。上传文档

Serum BDNF Concentrations Show Strong Seasonal Variation and Correlations with the Amount of Ambient Sunlight 英文参考文献

SerumBDNFConcentrationsShowStrongSeasonal VariationandCorrelationswiththeAmountofAmbient Sunlight MarcL.Molendijk1,2*,JudithP.M.Haffmans1,3,BoudewijnA.A.Bus4,PhilipSpinhoven1,2,5, BrendaW.J.H.Penninx5,6,7,JosPrickaerts8,RichardC.OudeVoshaar7,BernetM.Elzinga1,2 1Institute of Psychology, Leiden University, Leiden, The Netherlands, 2Leiden Institute for Brain and Cognition, Leiden University Medical Center, Leiden, The Netherlands, 3Parnassia-BAVO Group, Department of Affective Disorders, Medical Chronobiology, PsyQ, The Hague, The Netherlands, 4Department of Psychiatry RadboudUniversityMedicalCenter,Nijmegen,TheNetherlands,5DepartmentofPsychiatry,LeidenUniversityMedicalCenter,Leiden,TheNetherlands,6Departmentof Psychiatry, EMGO Institute and Neuroscience Campus Amsterdam, VU, Amsterdam, The Netherlands, 7University Center for Psychiatry, University Medical Center Groningen,UniversityofGroningen,Groningen,TheNetherlands,8DepartmentofPsychiatryandNeuropsychology,MaastrichtUniversity,Maastricht,TheNetherlands Abstract Earlier findings show seasonality in processes and behaviors such as brain plasticity and depression that in part are regulatedbyBrain-DerivedNeurotrophicFactor(BDNF).BasedonthisweinvestigatedseasonalvariationinserumBDNF concentrationsin2,851personswhotookpartintheNetherlandsStudyofDepressionandAnxiety(NESDA).Analysesby monthofsampling(monthlyn’s.196)showedpronouncedseasonalvariationinserumBDNFconcentrations(P,.0001) with increasing concentrations in the spring-summer period (standardized regression weight (?)=0.19, P,.0001) and decreasingconcentrationsintheautumn-winterperiod(?=20.17,P,.0001).Effectsizes[Cohen’sd]rangedfrom0.27to 0.66formonthlysignificantdifferences.WefoundsimilarseasonalvariationforbothsexesandforpersonswithaDSM-IV depressiondiagnosisandhealthycontrolsubjects.Inexplorativeanalyseswefoundthatthenumberofsunshinehours(a major trigger to entrain seasonality) in the week of blood withdrawal and the 10 weeks prior to this event positively cor